Home LiteratureArticle Details
PMID: 23540689 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Interplay between the cancer genome and epigenome.

Cell ·Vol. 153 ·No. 1 ·2013-03-28 ·Pages 38-55

Shen H, Laird PW

Abstract

Cancer arises as a consequence of cumulative disruptions to cellular growth control with Darwinian selection for those heritable changes that provide the greatest clonal advantage. These traits can be acquired and stably maintained by either genetic or epigenetic means. Here, we explore the ways in which alterations in the genome and epigenome influence each other and cooperate to promote oncogenic transformation. Disruption of epigenomic control is pervasive in malignancy and can be classified as an enabling characteristic of cancer cells, akin to genome instability and mutation.

MeSH Terms
Animals Cell Differentiation DNA Methylation Embryonic Development Epigenesis, Genetic Humans Neoplasms/genetics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Shen Hui
USC Epigenome Center, University of Southern California, Room G511B, 1450 Biggy Street, Los Angeles, CA 90089-9061, USA.
Laird Peter W
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2013.03.008
Published
2013-03-28
Pages
38-55
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC3648790
Subset
IM
Grants
NCI NIH HHS · U24 CA143882 · United States
NIDA NIH HHS · R01 DA030325 · United States
NCI NIH HHS · R01 CA157918 · United States
NIDA NIH HHS · R01-DA030325 · United States
NCI NIH HHS · R01 CA170550 · United States
NCI NIH HHS · R01-CA170550 · United States
NCI NIH HHS · R01-CA157918 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2013.03.008 PMC Full Text View journal details
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