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PMID: 24114910 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Septin functions in organ system physiology and pathology.

Biological chemistry ·Vol. 395 ·No. 2 ·2014-02-00 ·Pages 123-41

Dolat L, Hu Q, Spiliotis ET

Abstract

Human septins comprise a family of 13 genes that encode for >30 protein isoforms with ubiquitous and tissue-specific expressions. Septins are GTP-binding proteins that assemble into higher-order oligomers and filamentous polymers, which associate with cell membranes and the cytoskeleton. In the last decade, much progress has been made in understanding the biochemical properties and cell biological functions of septins. In parallel, a growing number of studies show that septins play important roles for the development and physiology of specific tissues and organs. Here, we review the expression and function of septins in the cardiovascular, immune, nervous, urinary, digestive, respiratory, endocrine, reproductive, and integumentary organ systems. Furthermore, we discuss how the tissue-specific functions of septins relate to the pathology of human diseases that arise from aberrations in septin expression.

MeSH Terms
Animals Embryonic Development/physiology Humans Organ Specificity Protein Conformation Protein Multimerization Septins/chemistry,genetics,physiology
Chemicals
Septins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dolat Lee
Hu Qicong
Spiliotis Elias T
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Article Info
Journal
Biological chemistry
Abbr.
Biol Chem
ISSN
1437-4315
DOI
10.1515/hsz-2013-0233
Published
2014-02-00
Pages
123-41
Language
English
Region
Germany
NLM ID
9700112
PMCID
PMC4452026
Subset
IM
Grants
NIGMS NIH HHS · R01 GM097664 · United States
NIGMS NIH HHS · GM097664 · United States
External Links
PubMed source DOI: 10.1515/hsz-2013-0233 PMC Full Text View journal details
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