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PMID: 24127133 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance.

Cellular and molecular life sciences : CMLS ·Vol. 71 ·No. 6 ·2014-03-00 ·Pages 1033-43

Winer DA, Winer S, Chng MH, Shen L, Engleman EG

Abstract

Obesity-related insulin resistance is a chronic inflammatory condition that often gives rise to type 2 diabetes (T2D). Much evidence supports a role for pro-inflammatory T cells and macrophages in promoting local inflammation in tissues such as visceral adipose tissue (VAT) leading to insulin resistance. More recently, B cells have emerged as an additional critical player in orchestrating these processes. B cells infiltrate VAT and display functional and phenotypic changes in response to diet-induced obesity. B cells contribute to insulin resistance by presenting antigens to T cells, secreting inflammatory cytokines, and producing pathogenic antibodies. B cell manipulation represents a novel approach to the treatment of obesity-related insulin resistance and potentially to the prevention of T2D. This review summarizes the roles of B cells in governing VAT inflammation and the mechanisms by which these cells contribute to altered glucose homeostasis in insulin resistance.

MeSH Terms
Animals B-Lymphocytes/immunology,pathology Diabetes Mellitus, Type 2/immunology Humans Inflammation/immunology,physiopathology Insulin Resistance/immunology,physiology Intra-Abdominal Fat/cytology,immunology Lymphocyte Activation/immunology Mice Mice, Inbred C57BL Obesity/immunology,pathology
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Winer Daniel A
Department of Pathology, Toronto General Hospital, University Health Network, University of Toronto, Eaton Wing, 11E - 424A, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada.
Winer Shawn
Chng Melissa H Y
Shen Lei
Engleman Edgar G
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Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-9071
DOI
10.1007/s00018-013-1486-y
Published
2014-03-00
Epub
2013-00-15
Pages
1033-43
Language
English
Region
Switzerland
NLM ID
9705402
PMCID
PMC3954849
Subset
IM
Grants
NIDDK NIH HHS · R01 DK096038 · United States
CIHR · 119414 · Canada
NIDDK NIH HHS · 1R01DK096038 · United States
External Links
PubMed source DOI: 10.1007/s00018-013-1486-y PMC Full Text View journal details
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