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PMID: 24137153 Published · epublish English Journal Article

Sleep-dependent synaptic down-selection (I): modeling the benefits of sleep on memory consolidation and integration.

Frontiers in neurology ·Vol. 4 ·2013-00-00 ·Pages 143

Nere A, Hashmi A, Cirelli C, Tononi G

Abstract

Sleep can favor the consolidation of both procedural and declarative memories, promote gist extraction, help the integration of new with old memories, and desaturate the ability to learn. It is often assumed that such beneficial effects are due to the reactivation of neural circuits in sleep to further strengthen the synapses modified during wake or transfer memories to different parts of the brain. A different possibility is that sleep may benefit memory not by further strengthening synapses, but rather by renormalizing synaptic strength to restore cellular homeostasis after net synaptic potentiation in wake. In this way, the sleep-dependent reactivation of neural circuits could result in the competitive down-selection of synapses that are activated infrequently and fit less well with the overall organization of memories. By using computer simulations, we show here that synaptic down-selection is in principle sufficient to explain the beneficial effects of sleep on the consolidation of procedural and declarative memories, on gist extraction, and on the integration of new with old memories, thereby addressing the plasticity-stability dilemma.

Keywords
declarative memory homeostatic regulation neurons plasticity and learning procedural memory sleep
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Nere Andrew
Department of Electrical and Computer Engineering, University of Wisconsin-Madison , Madison, WI , USA.
Hashmi Atif
Cirelli Chiara
Tononi Giulio
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Article Info
Journal
Frontiers in neurology
Abbr.
Front Neurol
ISSN
1664-2295
DOI
10.3389/fneur.2013.00143
Published
2013-00-00
Epub
2013-00-30
Pages
143
Language
English
Region
Switzerland
NLM ID
101546899
PMCID
PMC3786405
Grants
NIMH NIH HHS · R01 MH091326 · United States
External Links
PubMed source DOI: 10.3389/fneur.2013.00143 PMC Full Text View journal details
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