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PMID: 19400721 Published · ppublish English Journal Article Review

Synaptic mechanisms for plasticity in neocortex.

Annual review of neuroscience ·Vol. 32 ·2009-00-00 ·Pages 33-55

Feldman DE

Abstract

Sensory experience and learning alter sensory representations in cerebral cortex. The synaptic mechanisms underlying sensory cortical plasticity have long been sought. Recent work indicates that long-term cortical plasticity is a complex, multicomponent process involving multiple synaptic and cellular mechanisms. Sensory use, disuse, and training drive long-term potentiation and depression (LTP and LTD), homeostatic synaptic plasticity and plasticity of intrinsic excitability, and structural changes including formation, removal, and morphological remodeling of cortical synapses and dendritic spines. Both excitatory and inhibitory circuits are strongly regulated by experience. This review summarizes these findings and proposes that these mechanisms map onto specific functional components of plasticity, which occur in common across the primary somatosensory, visual, and auditory cortices.

MeSH Terms
Animals Cerebral Cortex/cytology,physiology Humans Long-Term Potentiation/physiology Neural Inhibition/physiology Neural Pathways/cytology,physiology Neuronal Plasticity/physiology Perception/physiology Sensation/physiology Synapses/physiology,ultrastructure Synaptic Transmission/physiology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Feldman Daniel E
Department of Molecular and Cell Biology, and Helen Wills Neuroscience Institute, University of California, Berkeley, USA. [email protected]
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Article Info
Journal
Annual review of neuroscience
Abbr.
Annu Rev Neurosci
ISSN
1545-4126
DOI
10.1146/annurev.neuro.051508.135516
Email
[email protected]
Published
2009-00-00
Pages
33-55
Language
English
Region
United States
NLM ID
7804039
PMCID
PMC3071739
Subset
IM
Grants
NINDS NIH HHS · R01 NS046652 · United States
NINDS NIH HHS · R01 NS046652-07A1 · United States
NINDS NIH HHS · R01 NS046652-08 · United States
External Links
PubMed source DOI: 10.1146/annurev.neuro.051508.135516 PMC Full Text View journal details
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