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PMID: 2437327 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoproteins.

Journal of virology ·Vol. 61 ·No. 6 ·1987-06-00 ·Pages 2024-8

Ho DD, Sarngadharan MG, Hirsch MS, Schooley RT, Rota TR, Kennedy RC, Chanh TC, Sato VL

Abstract

Serum neutralizing antibodies against the human immunodeficiency virus were frequently detected in infected individuals, and low or absent serum neutralizing titers correlated with poor prognosis. Multiple diverse human immunodeficiency virus isolates were found to exhibit similar susceptibility to neutralization by a panel of human seropositive sera, suggesting that neutralizing antibodies are largely directed against conserved viral domains. Furthermore, utilizing antisera raised against a library of synthetic env peptides, four regions which are important in the neutralization process have been identified within both human immunodeficiency virus envelope glycoproteins (gp41 and gp120). Three of these are in conserved domains and should be considered for inclusion in a candidate vaccine.

MeSH Terms
AIDS-Related Complex/immunology Acquired Immunodeficiency Syndrome/immunology Antibodies, Viral/immunology Epitopes/immunology Glycoproteins/immunology HIV/immunology HIV Antibodies Humans Male Neutralization Tests Peptide Fragments/immunology Prognosis Viral Envelope Proteins/immunology
Chemicals
Antibodies, Viral Epitopes Glycoproteins HIV Antibodies Peptide Fragments Viral Envelope Proteins
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Ho D D
Sarngadharan M G
Hirsch M S
Schooley R T
Rota T R
Kennedy R C
Chanh T C
Sato V L
References (28)
28 references, click to expand
  1. Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus.
    Nature. 1985 Feb 7-13;313(6002):450-8 PMID: 2982104
  2. Complete nucleotide sequence of the AIDS virus, HTLV-III.
    Nature. 1985 Jan 24-30;313(6000):277-84 PMID: 2578615
  3. Immunological properties of the Gag protein p24 of the acquired immunodeficiency syndrome retrovirus (human T-cell leukemia virus type III).
    Proc Natl Acad Sci U S A. 1985 May;82(10):3481-4 PMID: 2582414
  4. Neutralization of human T-lymphotropic virus type III by sera of AIDS and AIDS-risk patients.
    Nature. 1985 Jul 4-10;316(6023):69-72 PMID: 2989706
  5. HTLV-III-neutralizing antibodies in patients with AIDS and AIDS-related complex.
    Nature. 1985 Jul 4-10;316(6023):72-4 PMID: 2989707
  6. Immunological properties of HTLV-III antigens recognized by sera of patients with AIDS and AIDS-related complex and of asymptomatic carriers of HTLV-III infection.
    Cancer Res. 1985 Sep;45(9 Suppl):4574s-4577s PMID: 2410106
  7. Genomic diversity of human T-lymphotropic virus type III (HTLV-III).
    Science. 1985 Aug 23;229(4715):759-62 PMID: 2992084
  8. Detection of human anti-HTLV-III antibodies by indirect immunofluorescence using fixed cells.
    Transfusion. 1985 Jul-Aug;25(4):308-12 PMID: 2992128
  9. Characterization of gp41 as the transmembrane protein coded by the HTLV-III/LAV envelope gene.
    Science. 1985 Sep 27;229(4720):1402-5 PMID: 2994223
  10. Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome.
    N Engl J Med. 1985 Dec 12;313(24):1493-7 PMID: 2999591
  11. Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV.
    Science. 1986 Mar 14;231(4743):1289-91 PMID: 2418504
  12. Antiserum to a synthetic peptide recognizes the HTLV-III envelope glycoprotein.
    Science. 1986 Mar 28;231(4745):1556-9 PMID: 3006246
  13. Application of a modified computer algorithm in determining potential antigenic determinants associated with the AIDS virus glycoprotein.
    Anal Biochem. 1985 Dec;151(2):540-6 PMID: 2420228
  14. Infection of monocyte/macrophages by human T lymphotropic virus type III.
    J Clin Invest. 1986 May;77(5):1712-5 PMID: 2422213
  15. Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS.
    Cell. 1986 Jun 6;45(5):637-48 PMID: 2423250
  16. In vitro infection of human monocytes with human T lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV).
    J Immunol. 1986 Jul 1;137(1):323-9 PMID: 3011909
  17. Genetic variation in AIDS viruses.
    Cell. 1986 Jul 4;46(1):1-4 PMID: 3013415
  18. Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein.
    Science. 1986 Jul 11;233(4760):209-12 PMID: 3014647
  19. The role of mononuclear phagocytes in HTLV-III/LAV infection.
    Science. 1986 Jul 11;233(4760):215-9 PMID: 3014648
  20. Induction of anti-HIV neutralizing antibodies by synthetic peptides.
    EMBO J. 1986 Nov;5(11):3065-71 PMID: 3466790
  21. Use of anhydrous hydrogen fluoride in peptide synthesis. I. Behavior of various protective groups in anhydrous hydrogen fluoride.
    Bull Chem Soc Jpn. 1967 Sep;40(9):2164-7 PMID: 5583787
  22. Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody.
    J Exp Med. 1977 Jul 1;146(1):201-17 PMID: 406347
  23. Immunoprevention of Friend virus-induced erythroleukemia by vaccination with viral envelope glycoprotein complexes.
    Virology. 1981 Sep;113(2):602-12 PMID: 6943864
  24. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
    Science. 1983 May 20;220(4599):868-71 PMID: 6189183
  25. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS.
    Science. 1984 May 4;224(4648):497-500 PMID: 6200935
  26. Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS.
    Science. 1984 May 4;224(4648):506-8 PMID: 6324345
  27. HTLV-III in the semen and blood of a healthy homosexual man.
    Science. 1984 Oct 26;226(4673):451-3 PMID: 6208608
  28. Antibody to lymphadenopathy-associated virus in AIDS.
    N Engl J Med. 1985 Mar 7;312(10):649-50 PMID: 2983205
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.61.6.2024-2028.1987
Published
1987-06-00
Pages
2024-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254212
Subset
IM
Grants
NIAID NIH HHS · AI23472-01 · United States
NIAID NIH HHS · AI23619-01 · United States
NCI NIH HHS · CA35020 · United States
External Links
PubMed source DOI: 10.1128/JVI.61.6.2024-2028.1987 PMC Full Text View journal details
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