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PMID: 2441560 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A monoclonal antibody that recognizes a phosphorylated epitope in Alzheimer neurofibrillary tangles, neurofilaments and tau proteins immunostains granulovacuolar degeneration.

Acta neuropathologica ·Vol. 73 ·No. 3 ·1987-00-00 ·Pages 254-8

Dickson DW, Ksiezak-Reding H, Davies P, Yen SH

Abstract

A monoclonal antibody, raised against extracts from Alzheimer brain, that recognizes a phosphorylated epitope in high molecular weight neurofilament proteins and tau proteins also immunostains Alzheimer neurofibrillary tangles, neurites in senile plaques and granulovacuolar degeneration. This result suggest that granulovacuolar degeneration may contain phosphorylated proteins, possibly due to autophagy of phosphorylated perikaryal proteins that appear to be increased in Alzheimer's disease.

MeSH Terms
Alzheimer Disease/immunology,pathology Antibodies, Monoclonal/immunology Cytoskeleton/immunology Epitopes/analysis Histocytochemistry Humans Immunologic Techniques Intermediate Filaments/immunology,pathology Microtubule-Associated Proteins/immunology Nerve Degeneration Neurofibrils/immunology,pathology Phosphoproteins/immunology tau Proteins
Chemicals
Antibodies, Monoclonal Epitopes Microtubule-Associated Proteins Phosphoproteins tau Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Dickson D W
Ksiezak-Reding H
Davies P
Yen S H
References (19)
19 references, click to expand
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00686619
Published
1987-00-00
Pages
254-8
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
Grants
NIA NIH HHS · AG 1136 · United States
NIA NIH HHS · AG 4145 · United States
NINDS NIH HHS · NS 7098 · United States
External Links
PubMed source DOI: 10.1007/BF00686619 View journal details
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