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PMID: 2445686 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

A highly conserved region present in transcripts encoding heterologous M proteins of group A streptococci.

Infection and immunity ·Vol. 55 ·No. 12 ·1987-12-00 ·Pages 3237-9

Hollingshead SK, Fischetti VA, Scott JR

Abstract

In group A streptococcal strains of 10 different serotypes, the sequence previously identified as homologous to the structural gene for type 6 M protein (emm6) was found to be transcribed. The conserved sequence, which shows greater than 95% homology among heterologous M proteins, was identified as the 3' third of the gene.

MeSH Terms
Amino Acid Sequence Antigens, Bacterial Bacterial Outer Membrane Proteins Bacterial Proteins/genetics,immunology Carrier Proteins Epitopes Molecular Sequence Data RNA, Messenger/genetics Sequence Homology, Nucleic Acid Streptococcus pyogenes/genetics
Chemicals
Antigens, Bacterial Bacterial Outer Membrane Proteins Bacterial Proteins Carrier Proteins Epitopes RNA, Messenger streptococcal M protein
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hollingshead S K
Department of Microbiology and Immunology, Emory University Health Sciences Center, Atlanta, Georgia 30322.
Fischetti V A
Scott J R
References (18)
18 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.55.12.3237-3239.1987
Published
1987-12-00
Pages
3237-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC260060
Subset
IM
Grants
NIAID NIH HHS · AI20723 · United States
External Links
PubMed source DOI: 10.1128/iai.55.12.3237-3239.1987 PMC Full Text View journal details
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