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PMID: 2447127 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation.

The Journal of clinical investigation ·Vol. 81 ·No. 1 ·1988-01-00 ·Pages 92-7

Kaushansky K, Lin N, Adamson JW

Abstract

IL-1 is a family of polypeptides which play a critical role in the inflammatory response. Characteristics of this response include an enhanced release of bone marrow neutrophils, activation of circulating and tissue-phase phagocytes, and enhanced production of neutrophils and monocytes. We have sought to understand the hematopoietic response to acute and chronic inflammatory states on a cellular and molecular level. Colony-stimulating factors (CSFs) are glycoproteins involved in the production and activation of neutrophils and monocytes in vitro and in vivo. We have found that quiescent dermal fibroblasts constitutively release granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), and macrophage CSF in culture, and that picomolar concentrations of the inflammatory mediator IL-1 stimulate by at least fivefold the transcription and release of GM-CSF and G-CSF. These findings establish the role of IL-1 in the hematopoietic response to inflammation through the stimulation of the production and release of GM-CSF and G-CSF.

MeSH Terms
Animals Colony-Forming Units Assay Colony-Stimulating Factors/biosynthesis,classification Culture Media Fibroblasts/drug effects,metabolism Granulocytes Humans Interleukin-1/pharmacology Macrophages Mice Mice, Inbred Strains RNA/analysis
Chemicals
Colony-Stimulating Factors Culture Media Interleukin-1 RNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kaushansky K
Division of Hematology, University of Washington, Seattle 98195.
Lin N
Adamson J W
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI113316
Published
1988-01-00
Pages
92-7
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC442478
Subset
IM
Grants
NIADDK NIH HHS · AM-01304 · United States
NCI NIH HHS · CA-31615 · United States
External Links
PubMed source DOI: 10.1172/JCI113316 PMC Full Text View journal details
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