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PMID: 24489114 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The relation between recombination rate and patterns of molecular evolution and variation in Drosophila melanogaster.

Molecular biology and evolution ·Vol. 31 ·No. 4 ·2014-04-00 ·Pages 1010-28

Campos JL, Halligan DL, Haddrill PR, Charlesworth B

Abstract

Genetic recombination associated with sexual reproduction increases the efficiency of natural selection by reducing the strength of Hill-Robertson interference. Such interference can be caused either by selective sweeps of positively selected alleles or by background selection (BGS) against deleterious mutations. Its consequences can be studied by comparing patterns of molecular evolution and variation in genomic regions with different rates of crossing over. We carried out a comprehensive study of the benefits of recombination in Drosophila melanogaster, both by contrasting five independent genomic regions that lack crossing over with the rest of the genome and by comparing regions with different rates of crossing over, using data on DNA sequence polymorphisms from an African population that is geographically close to the putatively ancestral population for the species, and on sequence divergence from a related species. We observed reductions in sequence diversity in noncrossover (NC) regions that are inconsistent with the effects of hard selective sweeps in the absence of recombination. Overall, the observed patterns suggest that the recombination rate experienced by a gene is positively related to an increase in the efficiency of both positive and purifying selection. The results are consistent with a BGS model with interference among selected sites in NC regions, and joint effects of BGS, selective sweeps, and a past population expansion on variability in regions of the genome that experience crossing over. In such crossover regions, the X chromosome exhibits a higher rate of adaptive protein sequence evolution than the autosomes, implying a Faster-X effect.

Keywords
Drosophila melanogaster Hill–Robertson interference background selection crossing over heterochromatin recombination selective sweeps
MeSH Terms
Animals Chromosomes, Insect/genetics Crossing Over, Genetic Drosophila melanogaster/genetics Evolution, Molecular Female Genome, Insect Heterochromatin/genetics Male Models, Genetic Polymorphism, Single Nucleotide Recombination, Genetic Selection, Genetic X Chromosome/genetics
Chemicals
Heterochromatin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Campos José L
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Halligan Daniel L
Haddrill Penelope R
Charlesworth Brian
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Article Info
Journal
Molecular biology and evolution
Abbr.
Mol Biol Evol
ISSN
1537-1719
DOI
10.1093/molbev/msu056
Published
2014-04-00
Epub
2014-00-30
Pages
1010-28
Language
English
Region
United States
NLM ID
8501455
PMCID
PMC3969569
Subset
IM
Grants
Wellcome Trust · United Kingdom
Biotechnology and Biological Sciences Research Council · BB/H006028/1 · United Kingdom
Wellcome Trust · 088114 · United Kingdom
External Links
PubMed source DOI: 10.1093/molbev/msu056 PMC Full Text View journal details
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