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PMID: 24663220 Published · ppublish English Journal Article Review

Autophagy--a key player in cellular and body metabolism.

Nature reviews. Endocrinology ·Vol. 10 ·No. 6 ·2014-06-00 ·Pages 322-37

Kim KH, Lee MS

Abstract

Knowledge gained over the past 10 years about the mechanisms that underpin autophagy has provided a universal framework for studies of diverse physiological and pathological processes. Of particular interest is the emerging role of autophagy in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. Dysregulation of autophagy might contribute to the development of metabolic disorders, including insulin resistance, diabetes mellitus, obesity, atherosclerosis and osteoporosis. The authors of this Review highlight research findings on the regulation of cellular autophagy by nutrients. They also describe the role of autophagy in various tissues in the regulation of energy metabolism and the development of diseases related to altered metabolism. Finally, the potential of pharmacological modulation of autophagy as a treatment for human metabolic disorders is discussed.

MeSH Terms
Autophagy/drug effects,physiology Cells/metabolism Energy Metabolism/physiology Humans Insulin Resistance Metabolic Diseases/drug therapy,physiopathology Metabolism/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kim Kook Hwan
Department of Medicine and Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro Gangnam-gu, Seoul 135-710, Korea.
Lee Myung-Shik
Department of Medicine and Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro Gangnam-gu, Seoul 135-710, Korea.
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Article Info
Journal
Nature reviews. Endocrinology
Abbr.
Nat Rev Endocrinol
ISSN
1759-5037
DOI
10.1038/nrendo.2014.35
Published
2014-06-00
Epub
2014-00-25
Pages
322-37
Language
English
Region
England
NLM ID
101500078
Subset
IM
External Links
PubMed source DOI: 10.1038/nrendo.2014.35 View journal details
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