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PMID: 2473979 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Nucleotide sequence of the type C3 staphylococcal enterotoxin gene suggests that intergenic recombination causes antigenic variation.

Journal of bacteriology ·Vol. 171 ·No. 8 ·1989-08-00 ·Pages 4507-10

Couch JL, Betley MJ

Abstract

The nucleotide sequence of the structural gene for staphylococcal enterotoxin type C3 (entC3) was determined. This gene contains 798-base-pair open reading frame that encodes a protein of 266 amino acid residues. Sequence analysis suggests that staphylococcal enterotoxin type C3 is synthesized in a precursor form that is processed to yield a mature extracellular form of 238 amino acid residues (molecular weight, 27,438). The entC3 gene is closely related to the gene for staphylococcal enterotoxin type C1, with 98% nucleotide sequence identity. Sequence comparisons between the entC3, entC1, and entB genes suggest that an ancestral entC1-like gene was formed by recombination between the entC3 and entB genes.

MeSH Terms
Amino Acid Sequence Antigenic Variation Base Sequence Enterotoxins/genetics,immunology Epitopes/genetics Genes, Bacterial Molecular Sequence Data Recombination, Genetic Sequence Homology, Nucleic Acid Staphylococcus aureus/genetics
Chemicals
Enterotoxins Epitopes enterotoxin C, staphylococcal
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Couch J L
Department of Bacteriology, University of Wisconsin-Madison 53706.
Betley M J
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.171.8.4507-4510.1989
Published
1989-08-00
Pages
4507-10
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC210234
Subset
IM
Databases
GENBANK
M28364
External Links
PubMed source DOI: 10.1128/jb.171.8.4507-4510.1989 PMC Full Text View journal details
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