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PMID: 2493644 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

jun-D: a third member of the jun gene family.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 5 ·1989-03-00 ·Pages 1500-3

Ryder K, Lanahan A, Perez-Albuerne E, Nathans D

Abstract

The protooncogene c-jun encodes a component of the transcription factor AP-1. Both murine c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth factors. We report here the cloning and analysis of a cDNA encoding a third member of the murine jun family, jun-D. The amino acid sequence encoded by jun-D has two extensive regions of homology with the other Jun proteins. One homology region includes the DNA-binding domain and sequences required for dimer formation and interaction with the Fos oncoprotein; the other includes the acidic sequence thought to be involved in gene activation. All three jun mRNAs are present in a variety of murine tissues and cell lines. In resting 3T3 cells, jun-D is expressed at a higher level compared to c-jun and jun-B, and its transcription is stimulated only slightly by serum growth factors. Thus, jun-D appears to be regulated differently than c-jun and jun-B.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cells, Cultured DNA, Recombinant/isolation & purification DNA-Binding Proteins/genetics Mice Molecular Sequence Data Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-jun Proto-Oncogenes RNA, Messenger/genetics Sequence Homology, Nucleic Acid Transcription Factors/genetics Transcription, Genetic
Chemicals
DNA, Recombinant DNA-Binding Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins c-jun RNA, Messenger Transcription Factors
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ryder K
Howard Hughes Medical Institute Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Lanahan A
Perez-Albuerne E
Nathans D
References (28)
28 references, click to expand
  1. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  2. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.
    Science. 1988 Jun 24;240(4860):1759-64 PMID: 3289117
  3. Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts.
    Nature. 1988 Aug 11;334(6182):535-7 PMID: 3136397
  4. Induction of proto-oncogene JUN/AP-1 by serum and TPA.
    Nature. 1988 Aug 18;334(6183):629-31 PMID: 2457172
  5. Induction of protooncogene c-jun by serum growth factors.
    Proc Natl Acad Sci U S A. 1988 Nov;85(22):8464-7 PMID: 3186736
  6. DNA binding activities of three murine Jun proteins: stimulation by Fos.
    Cell. 1988 Dec 2;55(5):907-15 PMID: 3142691
  7. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities.
    Cell. 1988 Dec 2;55(5):917-24 PMID: 3142692
  8. The role of the leucine zipper in the fos-jun interaction.
    Nature. 1988 Dec 15;336(6200):646-51 PMID: 2974122
  9. Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.
    Genes Dev. 1988 Dec;2(12B):1687-99 PMID: 2467839
  10. Genomic response to growth factors.
    Cold Spring Harb Symp Quant Biol. 1988;53 Pt 2:893-900 PMID: 3151190
  11. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
    Biochemistry. 1979 Nov 27;18(24):5294-9 PMID: 518835
  12. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
    Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5 PMID: 6159641
  13. Isolation and partial characterization of the Drosophila alcohol dehydrogenase gene.
    Proc Natl Acad Sci U S A. 1980 Oct;77(10):5794-8 PMID: 6777776
  14. Lambda replacement vectors carrying polylinker sequences.
    J Mol Biol. 1983 Nov 15;170(4):827-42 PMID: 6315951
  15. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.
    Nature. 1984 Oct 4-10;311(5985):433-8 PMID: 6090941
  16. Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.
    EMBO J. 1985 Dec 1;4(12):3145-51 PMID: 3841511
  17. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.
    Cell. 1986 Aug 29;46(5):659-67 PMID: 3488815
  18. Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.
    Proc Natl Acad Sci U S A. 1987 Mar;84(5):1182-6 PMID: 3469660
  19. Avian sarcoma virus 17 carries the jun oncogene.
    Proc Natl Acad Sci U S A. 1987 May;84(9):2848-52 PMID: 3033666
  20. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.
    Cell. 1987 Jun 19;49(6):729-39 PMID: 3034432
  21. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements.
    Cell. 1987 Jun 19;49(6):741-52 PMID: 3034433
  22. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.
    Science. 1987 Dec 4;238(4832):1386-92 PMID: 2825349
  23. Transcriptional regulation of hemoglobin switching in chicken embryos.
    Mol Cell Biol. 1981 Mar;1(3):281-8 PMID: 6086008
  24. A gene activated by growth factors is related to the oncogene v-jun.
    Proc Natl Acad Sci U S A. 1988 Mar;85(5):1487-91 PMID: 3422745
  25. v-jun encodes a nuclear protein with enhancer binding properties of AP-1.
    Cell. 1988 Mar 11;52(5):705-12 PMID: 2830989
  26. Oncogene jun encodes a sequence-specific trans-activator similar to AP-1.
    Nature. 1988 Mar 10;332(6160):166-71 PMID: 3347253
  27. The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast.
    Nature. 1988 Apr 14;332(6165):649-50 PMID: 3128739
  28. Transcriptional autoregulation of the proto-oncogene fos.
    Nature. 1988 Jul 28;334(6180):314-9 PMID: 2839774
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.5.1500
Published
1989-03-00
Pages
1500-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286724
Subset
IM
Grants
NCI NIH HHS · 5 P01 CA16519 · United States
NIGMS NIH HHS · GM 07309 · United States
Databases
GENBANK
J04509
External Links
PubMed source DOI: 10.1073/pnas.86.5.1500 PMC Full Text View journal details
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