Outer membrane alterations in multiresistant mutants of Pseudomonas aeruginosa selected by ciprofloxacin.

Antimicrobial agents and chemotherapy ·Vol. 33 ·No. 1 ·1989-01-00 ·Pages 124-7

Legakis NJ, Tzouvelekis LS, Makris A, Kotsifaki H

Abstract

Spontaneous mutants of Pseudomonas aeruginosa selected by ciprofloxacin were studied for outer membrane alterations. Acquisition of ciprofloxacin resistance was at least partially related to defects in lipopolysaccharide synthesis. When ciprofloxacin resistance was combined with resistance to beta-lactams and aminoglycosides, several alterations in outer membrane proteins were noted.

MeSH Terms

Bacterial Outer Membrane Proteins/metabolism Ciprofloxacin/pharmacology Drug Resistance, Microbial Pseudomonas aeruginosa/drug effects,metabolism,ultrastructure

Chemicals

Bacterial Outer Membrane Proteins Ciprofloxacin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Legakis N J

Department of Microbiology, School of Health Sciences, Goudi, Athens, Greece.

Tzouvelekis L S

Makris A

Kotsifaki H

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25 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.33.1.124

Published

1989-01-00

Pages

124-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC171437

Subset

External Links

PubMed source DOI: 10.1128/AAC.33.1.124 PMC Full Text View journal details

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Outer membrane alterations in multiresistant mutants of Pseudomonas aeruginosa selected by ciprofloxacin.

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