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PMID: 2504481 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Immunopathology of Schistosoma mansoni infection.

Clinical microbiology reviews ·Vol. 2 ·No. 3 ·1989-07-00 ·Pages 250-69

Boros DL

Abstract

Schistosomiasis mansoni is a chronic helminthic disease that affects about 100 million people in the tropics. The worms have a life span of 5 to 10 years, and they live in the mesenteric veins of the host. Lightly infected individuals are asymptomatic or manifest mild intestinal symptoms. Heavily infected individuals often develop severe morbidity with hepatosplenomegaly, sometimes with a fatal outcome. Morbidity is attributed to the strong humoral and T-cell-mediated host immune responses developed to a variety of parasite antigens and expressed as tissue inflammations. The immunopathology includes dermatitis, immune complex-mediated kidney disease, and, chiefly, T-cell-mediated granuloma formation and fibrosis around disseminated parasite eggs. This review describes the mechanisms of induction and expression of immunopathology in infected persons and experimental animals. Immunoregulatory mechanisms that modulate the enhanced immune responses and may ameliorate excessive morbidity are discussed.

MeSH Terms
Acute Disease Animals Antigens, Helminth/immunology Chronic Disease Dermatitis/immunology,parasitology Humans Schistosoma mansoni/physiology Schistosomiasis mansoni/immunology,pathology
Chemicals
Antigens, Helminth
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Boros D L
Department of Immunology and Microbiology, School of Medicine, Wayne State University, Detroit, Michigan 48201.
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Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.2.3.250
Published
1989-07-00
Pages
250-69
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC358119
Subset
IM
Grants
NIAID NIH HHS · AI-12913 · United States
External Links
PubMed source DOI: 10.1128/CMR.2.3.250 PMC Full Text View journal details
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