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PMID: 25352272 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Promoter-based integration in plant defense regulation.

Plant physiology ·Vol. 166 ·No. 4 ·2014-12-00 ·Pages 1803-20

Li B, Gaudinier A, Tang M, Taylor-Teeples M, Nham NT, Ghaffari C, Benson DS, Steinmann M, Gray JA, Brady SM, Kliebenstein DJ

Abstract

A key unanswered question in plant biology is how a plant regulates metabolism to maximize performance across an array of biotic and abiotic environmental stresses. In this study, we addressed the potential breadth of transcriptional regulation that can alter accumulation of the defensive glucosinolate metabolites in Arabidopsis (Arabidopsis thaliana). A systematic yeast one-hybrid study was used to identify hundreds of unique potential regulatory interactions with a nearly complete complement of 21 promoters for the aliphatic glucosinolate pathway. Conducting high-throughput phenotypic validation, we showed that >75% of tested transcription factor (TF) mutants significantly altered the accumulation of the defensive glucosinolates. These glucosinolate phenotypes were conditional upon the environment and tissue type, suggesting that these TFs may allow the plant to tune its defenses to the local environment. Furthermore, the pattern of TF/promoter interactions could partially explain mutant phenotypes. This work shows that defense chemistry within Arabidopsis has a highly intricate transcriptional regulatory system that may allow for the optimization of defense metabolite accumulation across a broad array of environments.

MeSH Terms
Arabidopsis/genetics,immunology,physiology Arabidopsis Proteins/genetics,metabolism Cluster Analysis Environment Gene Expression Regulation, Plant Gene Regulatory Networks Glucosinolates/metabolism Mutagenesis, Insertional Phenotype Plants, Genetically Modified Promoter Regions, Genetic/genetics Saccharomyces cerevisiae/genetics,metabolism Stress, Physiological Transcription Factors/genetics,metabolism
Chemicals
Arabidopsis Proteins Glucosinolates Transcription Factors
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Li Baohua
Departments of Plant Sciences (B.L., M.T., N.T.N. C.G., D.S.B., M.S., J.A.G., D.J.K.) and Plant Biology (A.G., M.T., M.T.-T., J.A.G., S.M.B.) and Genome Center (A.G., M.T., M.T.-T., J.A.G., S.M.B.), University of California, Davis, California 95616; andDynaMo Center of Excellence, University of Copenhagen, DK-1871 Frederiksberg C, Denmark (D.J.K.).
Gaudinier Allison
Departments of Plant Sciences (B.L., M.T., N.T.N. C.G., D.S.B., M.S., J.A.G., D.J.K.) and Plant Biology (A.G., M.T., M.T.-T., J.A.G., S.M.B.) and Genome Center (A.G., M.T., M.T.-T., J.A.G., S.M.B.), University of California, Davis, California 95616; andDynaMo Center of Excellence, University of Copenhagen, DK-1871 Frederiksberg C, Denmark (D.J.K.).
Tang Michelle
Departments of Plant Sciences (B.L., M.T., N.T.N. C.G., D.S.B., M.S., J.A.G., D.J.K.) and Plant Biology (A.G., M.T., M.T.-T., J.A.G., S.M.B.) and Genome Center (A.G., M.T., M.T.-T., J.A.G., S.M.B.), University of California, Davis, California 95616; andDynaMo Center of Excellence, University of Copenhagen, DK-1871 Frederiksberg C, Denmark (D.J.K.).
Taylor-Teeples Mallorie
Departments of Plant Sciences (B.L., M.T., N.T.N. C.G., D.S.B., M.S., J.A.G., D.J.K.) and Plant Biology (A.G., M.T., M.T.-T., J.A.G., S.M.B.) and Genome Center (A.G., M.T., M.T.-T., J.A.G., S.M.B.), University of California, Davis, California 95616; andDynaMo Center of Excellence, University of Copenhagen, DK-1871 Frederiksberg C, Denmark (D.J.K.).
Nham Ngoc T
Departments of Plant Sciences (B.L., M.T., N.T.N. C.G., D.S.B., M.S., J.A.G., D.J.K.) and Plant Biology (A.G., M.T., M.T.-T., J.A.G., S.M.B.) and Genome Center (A.G., M.T., M.T.-T., J.A.G., S.M.B.), University of California, Davis, California 95616; andDynaMo Center of Excellence, University of Copenhagen, DK-1871 Frederiksberg C, Denmark (D.J.K.).
Ghaffari Cyrus
Departments of Plant Sciences (B.L., M.T., N.T.N. C.G., D.S.B., M.S., J.A.G., D.J.K.) and Plant Biology (A.G., M.T., M.T.-T., J.A.G., S.M.B.) and Genome Center (A.G., M.T., M.T.-T., J.A.G., S.M.B.), University of California, Davis, California 95616; andDynaMo Center of Excellence, University of Copenhagen, DK-1871 Frederiksberg C, Denmark (D.J.K.).
Benson Darik Scott
Departments of Plant Sciences (B.L., M.T., N.T.N. C.G., D.S.B., M.S., J.A.G., D.J.K.) and Plant Biology (A.G., M.T., M.T.-T., J.A.G., S.M.B.) and Genome Center (A.G., M.T., M.T.-T., J.A.G., S.M.B.), University of California, Davis, California 95616; andDynaMo Center of Excellence, University of Copenhagen, DK-1871 Frederiksberg C, Denmark (D.J.K.).
Steinmann Margaret
Departments of Plant Sciences (B.L., M.T., N.T.N. C.G., D.S.B., M.S., J.A.G., D.J.K.) and Plant Biology (A.G., M.T., M.T.-T., J.A.G., S.M.B.) and Genome Center (A.G., M.T., M.T.-T., J.A.G., S.M.B.), University of California, Davis, California 95616; andDynaMo Center of Excellence, University of Copenhagen, DK-1871 Frederiksberg C, Denmark (D.J.K.).
Gray Jennifer A
Departments of Plant Sciences (B.L., M.T., N.T.N. C.G., D.S.B., M.S., J.A.G., D.J.K.) and Plant Biology (A.G., M.T., M.T.-T., J.A.G., S.M.B.) and Genome Center (A.G., M.T., M.T.-T., J.A.G., S.M.B.), University of California, Davis, California 95616; andDynaMo Center of Excellence, University of Copenhagen, DK-1871 Frederiksberg C, Denmark (D.J.K.).
Brady Siobhan M
Departments of Plant Sciences (B.L., M.T., N.T.N. C.G., D.S.B., M.S., J.A.G., D.J.K.) and Plant Biology (A.G., M.T., M.T.-T., J.A.G., S.M.B.) and Genome Center (A.G., M.T., M.T.-T., J.A.G., S.M.B.), University of California, Davis, California 95616; andDynaMo Center of Excellence, University of Copenhagen, DK-1871 Frederiksberg C, Denmark (D.J.K.).
Kliebenstein Daniel J
Departments of Plant Sciences (B.L., M.T., N.T.N. C.G., D.S.B., M.S., J.A.G., D.J.K.) and Plant Biology (A.G., M.T., M.T.-T., J.A.G., S.M.B.) and Genome Center (A.G., M.T., M.T.-T., J.A.G., S.M.B.), University of California, Davis, California 95616; andDynaMo Center of Excellence, University of Copenhagen, DK-1871 Frederiksberg C, Denmark (D.J.K.) [email protected].
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Article Info
Journal
Plant physiology
Abbr.
Plant Physiol
ISSN
1532-2548
DOI
10.1104/pp.114.248716
Email
[email protected]
Published
2014-12-00
Epub
2014-00-28
Pages
1803-20
Language
English
Region
United States
NLM ID
0401224
PMCID
PMC4256871
Subset
IM
External Links
PubMed source DOI: 10.1104/pp.114.248716 PMC Full Text View journal details
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