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PMID: 25374356 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Axonal transport: cargo-specific mechanisms of motility and regulation.

Neuron ·Vol. 84 ·No. 2 ·2014-10-22 ·Pages 292-309

Maday S, Twelvetrees AE, Moughamian AJ, Holzbaur EL

Abstract

Axonal transport is essential for neuronal function, and many neurodevelopmental and neurodegenerative diseases result from mutations in the axonal transport machinery. Anterograde transport supplies distal axons with newly synthesized proteins and lipids, including synaptic components required to maintain presynaptic activity. Retrograde transport is required to maintain homeostasis by removing aging proteins and organelles from the distal axon for degradation and recycling of components. Retrograde axonal transport also plays a major role in neurotrophic and injury response signaling. This review provides an overview of axonal transport pathways and discusses their role in neuronal function.

MeSH Terms
Animals Axonal Transport/physiology Axons/physiology Humans Neurodegenerative Diseases/metabolism Neurons/metabolism Organelles/metabolism Signal Transduction/physiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Maday Sandra
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 638A Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104-6085 USA.
Twelvetrees Alison E
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 638A Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104-6085 USA.
Moughamian Armen J
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 638A Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104-6085 USA.
Holzbaur Erika L F
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 638A Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104-6085 USA. Electronic address: [email protected].
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Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
1097-4199
DOI
10.1016/j.neuron.2014.10.019
Email
[email protected]
Published
2014-10-22
Epub
2014-00-22
Pages
292-309
Language
English
Region
United States
NLM ID
8809320
PMCID
PMC4269290
Subset
IM
Grants
NINDS NIH HHS · R37 NS060698 · United States
NIA NIH HHS · T32AG000255 · United States
Wellcome Trust · 096141/Z/11/Z · United Kingdom
NINDS NIH HHS · K99NS082619 · United States
NINDS NIH HHS · K99 NS082619 · United States
NINDS NIH HHS · F31 NS073196 · United States
NINDS NIH HHS · F31NS073196 · United States
External Links
PubMed source DOI: 10.1016/j.neuron.2014.10.019 PMC Full Text View journal details
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