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PMID: 2552445 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Z-DNA-forming sequences are spontaneous deletion hot spots.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 19 ·1989-10-00 ·Pages 7465-9

Freund AM, Bichara M, Fuchs RP

Abstract

Z-DNA-forming sequences are shown to elicit a biological response in Escherichia coli. Plasmids containing sequences capable of adopting the Z conformation (GC and CA/GT) are shown to be hot spots for spontaneous deletions. All the deletions involve an even number of base pairs. The distribution of the deletion events shows that the process ends when the Z-DNA-forming sequence has been reduced to a size no longer capable of adopting the Z conformation at natural superhelical density.

MeSH Terms
Chromosome Deletion DNA Transposable Elements DNA, Bacterial/genetics,isolation & purification DNA, Superhelical/genetics Electrophoresis, Gel, Two-Dimensional Mutation Nucleic Acid Conformation Phenotype Plasmids
Chemicals
DNA Transposable Elements DNA, Bacterial DNA, Superhelical
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Freund A M
Groupe de Cancérogénèse et de Mutagénèse Moléculaire et Structurale, Centre National de la Recherche Scientifique, Strasbourg, France.
Bichara M
Fuchs R P
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.19.7465
Published
1989-10-00
Pages
7465-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC298085
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.86.19.7465 PMC Full Text View journal details
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