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PMID: 25699984 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

The periconceptional environment and cardiovascular disease: does in vitro embryo culture and transfer influence cardiovascular development and health?

Nutrients ·Vol. 7 ·No. 3 ·2015-02-18 ·Pages 1378-425

Padhee M, Zhang S, Lie S, Wang KC, Botting KJ, McMillen IC, MacLaughlin SM, Morrison JL

Abstract

Assisted Reproductive Technologies (ARTs) have revolutionised reproductive medicine; however, reports assessing the effects of ARTs have raised concerns about the immediate and long-term health outcomes of the children conceived through ARTs. ARTs include manipulations during the periconceptional period, which coincides with an environmentally sensitive period of gamete/embryo development and as such may alter cardiovascular development and health of the offspring in postnatal life. In order to identify the association between ARTs and cardiovascular health outcomes, it is important to understand the events that occur during the periconceptional period and how they are affected by procedures involved in ARTs. This review will highlight the emerging evidence implicating adverse cardiovascular outcomes before and after birth in offspring conceived through ARTs in both human and animal studies. In addition, it will identify the potential underlying causes and molecular mechanisms responsible for the congenital and adult cardiovascular dysfunctions in offspring whom were conceived through ARTs.

MeSH Terms
Animals Cardiovascular Diseases/etiology Embryonic Development Female Fertilization in Vitro/adverse effects Humans Pregnancy Pregnancy Outcome
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Padhee Monalisa
Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. [email protected].
Zhang Song
Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. [email protected].
Lie Shervi
Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. [email protected].
Wang Kimberley C
Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. [email protected].
Botting Kimberley J
Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. [email protected].
McMillen I Caroline
Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. [email protected].
MacLaughlin Severence M
Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. [email protected].
Morrison Janna L
Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia. [email protected].
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Article Info
Journal
Nutrients
Abbr.
Nutrients
ISSN
2072-6643
DOI
10.3390/nu7031378
Email
[email protected]
[email protected]
[email protected]
[email protected]
[email protected]
[email protected]
[email protected]
[email protected]
Published
2015-02-18
Epub
2015-00-18
Pages
1378-425
Language
English
Region
Switzerland
NLM ID
101521595
PMCID
PMC4377860
Subset
IM
External Links
PubMed source DOI: 10.3390/nu7031378 PMC Full Text View journal details
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