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PMID: 2668873 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

An ARS/silencer binding factor also activates two ribosomal protein genes in yeast.

Nucleic acids research ·Vol. 17 ·No. 13 ·1989-07-11 ·Pages 4917-23

Dorsman JC, Doorenbosch MM, Maurer CT, de Winde JH, Mager WH, Planta RJ, Grivell LA

Abstract

GFI is an abundant yeast DNA-binding protein, capable of binding to both ARS sequences and to the upstream regions of a number of nuclear genes coding for mitochondrial proteins (Dorsman et al., Nucl. Acids Res., 16 [1988] 7287-7301). GFI binding sites conform to the consensus RTCRYN5ACG, an element also present in the binding sites of factors designated SUF and TAF. These factors act as trans-activators of the constitutive transcription of the genes for ribosomal proteins S33 and L3 respectively. We now present evidence that GFI, TAF and SUF are probably the same protein. We speculate that one of the functions of GFI is the adjustment of the expression of a number of gene families to cell growth rate.

MeSH Terms
Base Sequence DNA-Binding Proteins/metabolism Genes Genes, Fungal Methylation Molecular Sequence Data Oligonucleotide Probes Ribosomal Proteins/genetics Saccharomyces cerevisiae/genetics Transcription, Genetic
Chemicals
DNA-Binding Proteins Oligonucleotide Probes Ribosomal Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Dorsman J C
Department of Molecular Cell Biology, University of Amsterdam, The Netherlands.
Doorenbosch M M
Maurer C T
de Winde J H
Mager W H
Planta R J
Grivell L A
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/17.13.4917
Published
1989-07-11
Pages
4917-23
Language
English
Region
England
NLM ID
0411011
PMCID
PMC318083
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/17.13.4917 PMC Full Text View journal details
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