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PMID: 2692519 Published · ppublish English Journal Article

Adhesion molecule mapping in normal human skin.

Archives of dermatological research ·Vol. 281 ·No. 7 ·1989-00-00 ·Pages 454-62

Konter U, Kellner I, Klein E, Kaufmann R, Mielke V, Sterry W

Abstract

Adhesion molecules are a rapidly growing group of cell surface receptors providing cell-cell and cell-matrix interactions. Their physiological role in tissue homeostasis as well as cellular migration and differentiation is increasingly appreciated. In the present study we have analyzed the expression pattern of most adhesion molecules of the integrin family as well as of adhesion molecules belonging to the immunoglobulin superfamily in normal human skin. We provide evidence that expression of adhesion molecules in the various cutaneous cell systems follows a constant distribution. Moreover, the physiological mononuclear infiltrate of the skin also expresses a variety of adhesion molecules enabeling these cells to migrate or to reside within the skin. Furthermore, our results indicate that intercellular adhesion molecule-1 is not a prerequisite for lymphocyte epidermotropism as frequently stated. Our data provide a rational basis to analyze changing adhesion molecule expression in inflammatory and neoplastic skin diseases.

MeSH Terms
Adult Aged Aged, 80 and over Amino Acid Sequence Antibodies, Monoclonal Cell Adhesion Molecules/analysis Humans Immunoenzyme Techniques Immunoglobulins/classification,immunology Integrins/analysis Middle Aged Molecular Sequence Data Skin/analysis
Chemicals
Antibodies, Monoclonal Cell Adhesion Molecules Immunoglobulins Integrins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Konter U
Department of Dermatology, University of Kiel, Federal Republic of Germany.
Kellner I
Klein E
Kaufmann R
Mielke V
Sterry W
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Article Info
Journal
Archives of dermatological research
Abbr.
Arch Dermatol Res
ISSN
0340-3696
DOI
10.1007/BF00510080
Published
1989-00-00
Pages
454-62
Language
English
Region
Germany
NLM ID
8000462
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00510080 View journal details
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