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PMID: 27461 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

Immuno-stimulation by a ribosomal vaccine associated with a bacterial cell wall adjuvant in humans.

Infection and immunity ·Vol. 20 ·No. 3 ·1978-06-00 ·Pages 760-9

Michel FB, Dussourd D'Hinterland L, Bousquet J, Pinel AM, Normier G

Abstract

We have studied a new vaccine of ribosomal nature associated with glycoprotein cell walls from Klebsiella pneumoniae which served as an immunoadjuvant. Thus vaccine was administered by the aerosol route to working men free of any important disease, especially of respiratory disease. A total of 104 men working for the Commissariat à l'Energie Atomique, all volunteers, were randomly placed into two groups. During the first period, 51 patients (group I) were vaccinated three times a week during 5 weeks, and the second group was used as control. During the second period, which started on day 225, the control group received the vaccine, and the first group was revaccinated. Results of this experience show a significant difference in the immunity of the two groups. The specific antibodies increased with vaccination as illustrated by chi-square test (Yates correction), which corresponds to an independent probability equal to 0 (P = 0.5 X 10-4).

MeSH Terms
Adjuvants, Immunologic Antibodies, Bacterial/biosynthesis Antibody Specificity Bacterial Vaccines Cell Wall/immunology Haemophilus influenzae/immunology Humans Klebsiella pneumoniae/immunology Male Ribosomes/immunology Streptococcus pneumoniae/immunology Streptococcus pyogenes/immunology Time Factors
Chemicals
Adjuvants, Immunologic Antibodies, Bacterial Bacterial Vaccines
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Michel F B
Dussourd D'Hinterland L
Bousquet J
Pinel A M
Normier G
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38 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.20.3.760-769.1978
Published
1978-06-00
Pages
760-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421924
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.20.3.760-769.1978 PMC Full Text View journal details
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