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PMID: 4199718 Published · ppublish English Journal Article

Ribosomal vaccines. II. Specificity of the immune response to ribosomal ribonucleic acid and protein isolated from Salmonella typhimurium.

Infection and immunity ·Vol. 8 ·No. 3 ·1973-09-00 ·Pages 395-400

Johnson W

Abstract

Ribosomal proteins isolated from Salmonella typhimurium were effective in inducing immunity in mice. This immunity was specific since animals immunized with ribosomal proteins from S. typhimurium were not protected against challenge with S. cholerae-suis or S. enteritidis. Immunity was evident as early as 5 days after immunization. Ribosomal ribonucleic acid (RNA) failed to provide any effective immunity in mice. Polyinosinic acid: polycytidylic acid (poly I: C) induced a rapid, short-lived immunity to all three Salmonella species. In contrast, ribosomal RNA failed to elicit any rapid nonspecific response to infection.

MeSH Terms
Animals Antibody Formation Antibody Specificity Antigens, Bacterial Bacterial Proteins/analysis Bacterial Vaccines Bacteriological Techniques DNA, Bacterial/analysis Endotoxins/analysis Hemagglutination Tests Immune Sera Immunization Immunodiffusion Male Mice Poly I-C RNA, Bacterial/analysis RNA, Ribosomal Ribosomes Salmonella typhimurium/immunology
Chemicals
Antigens, Bacterial Bacterial Proteins Bacterial Vaccines DNA, Bacterial Endotoxins Immune Sera RNA, Bacterial RNA, Ribosomal Poly I-C
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Johnson W
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25 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.8.3.395-400.1973
Published
1973-09-00
Pages
395-400
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422861
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.8.3.395-400.1973 PMC Full Text View journal details
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