Allantoin transport in Saccharomyces cerevisiae is regulated by two induction systems.
We show that the allantoin transport system of Saccharomyces cerevisiae responds to two induction systems, one mediated by allophanate or its analog oxalurate and the other mediated by allantoin or its analog hydantoin acetate. The effects of the two inducers were additive in strain M85. Like other allantoin pathway genes, oxalurate-mediated induction of allantoin transport required a functional DAL81 gene product. Hydantoin acetate-mediated induction of the system, on the other hand, occurred normally in dal81 mutants. This suggests that induction was not only mediated by two separate inducers, but also involved different regulatory proteins. Induction is probably a transcriptionally regulated process, because addition of hydantoin acetate or oxalurate to the culture medium increased the steady-state levels of mRNA encoded by a gene required for allantoin transport (DAL4).
19 references, click to expand
-
Isolation of genes by complementation in yeast: molecular cloning of a cell-cycle gene.Proc Natl Acad Sci U S A. 1980 Apr;77(4):2119-23 PMID: 6246523
-
High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.Proc Natl Acad Sci U S A. 1979 Mar;76(3):1035-9 PMID: 375221
-
Allantoin transport in Saccharomyces cerevisiae.J Bacteriol. 1977 Sep;131(3):839-47 PMID: 19421
-
Isolation and characterization of mutants that produce the allantoin-degrading enzymes constitutively in Saccharomyces cerevisiae.Mol Cell Biol. 1982 Sep;2(9):1088-95 PMID: 6757722
-
Identification of the ureidoglycolate hydrolase gene in the DAL gene cluster of Saccharomyces cerevisiae.Mol Cell Biol. 1985 Sep;5(9):2279-88 PMID: 3915539
-
Kinetics of induced and repressed enzyme synthesis in Saccharomyces cerevisiae.J Bacteriol. 1975 Mar;121(3):1064-73 PMID: 1090586
-
Clustering of the genes for allantoin degradation in Saccharomyces cerevisiae.J Bacteriol. 1974 Aug;119(2):461-8 PMID: 4604238
-
A cluster of three genes responsible for allantoin degradation in Saccharomyces cerevisiae.Genetics. 1979 Jun;92(2):383-96 PMID: 385448
-
Two differentially regulated mRNAs with different 5' ends encode secreted with intracellular forms of yeast invertase.Cell. 1982 Jan;28(1):145-54 PMID: 7039847
-
Biochemical Mutants in the Smut Fungus Ustilago Maydis.Genetics. 1949 Sep;34(5):607-26 PMID: 17247336
-
Oxaluric acid: a non-metabolizable inducer of the allantoin degradative enzymes in Saccharomyces cerevisiae.J Bacteriol. 1974 Mar;117(3):1240-7 PMID: 4591950
-
Urea transport-defective strains of Saccharomyces cerevisiae.J Bacteriol. 1976 Mar;125(3):1048-56 PMID: 3491
-
Induction of the allantoin degradative enzymes in Saccharomyces cerevisiae by the last intermediate of the pathway.Proc Natl Acad Sci U S A. 1973 Aug;70(8):2340-4 PMID: 4599622
-
Metabolite compartmentation in Saccharomyces cerevisiae.J Bacteriol. 1978 Aug;135(2):490-7 PMID: 355230
-
Pleiotropic control of five eucaryotic genes by multiple regulatory elements.J Bacteriol. 1982 Sep;151(3):1237-46 PMID: 7050082
-
Induction and inhibition of the allantoin permease in Saccharomyces cerevisiae.J Bacteriol. 1978 Aug;135(2):498-510 PMID: 355231
-
Isolation of the CAR1 gene from Saccharomyces cerevisiae and analysis of its expression.Mol Cell Biol. 1982 Dec;2(12):1514-23 PMID: 14582193
-
Cloning and transcriptional control of a eucaryotic permease gene.Mol Cell Biol. 1982 Aug;2(8):977-84 PMID: 6290876
-
The crystal structure of DL-allantoin.Acta Crystallogr. 1965 Nov 10;19(5):726-34 PMID: 5897688
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
