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PMID: 28357331 Published · epublish English Journal Article Review

Autophagy: machinery and regulation.

Microbial cell (Graz, Austria) ·Vol. 3 ·No. 12 ·2016-12-01 ·Pages 588-596

Yin Z, Pascual C, Klionsky DJ

Abstract

Macroautophagy/autophagy is an evolutionarily conserved cellular degradation process that targets cytoplasmic materials including cytosol, macromolecules and unwanted organelles. The discovery and analysis of autophagy-related (Atg) proteins have unveiled much of the machinery of autophagosome formation. Although initially autophagy was regarded as a survival response to stress, recent studies have revealed its significance in cellular and organismal homeostasis, development and immunity. Autophagic dysfunction and dysregulation are implicated in various diseases. In this review, we briefly summarize the physiological roles, molecular mechanism, regulatory network, and pathophysiological roles of autophagy.

Keywords
autophagosome formation autophagy cellular homeostasis pathogenesis physiological roles regulation
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yin Zhangyuan
Life Sciences Institute, and Department of Molecular, Cellular and Developmental Biology; University of Michigan, Ann Arbor, MI, USA 48109.
Pascual Clarence
Life Sciences Institute, and Department of Molecular, Cellular and Developmental Biology; University of Michigan, Ann Arbor, MI, USA 48109.
Klionsky Daniel J
Life Sciences Institute, and Department of Molecular, Cellular and Developmental Biology; University of Michigan, Ann Arbor, MI, USA 48109.
Conflict of Interest

Conflict of interest: The authors declare no conflict of interest.

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Article Info
Journal
Microbial cell (Graz, Austria)
Abbr.
Microb Cell
ISSN
2311-2638
DOI
10.15698/mic2016.12.546
Published
2016-12-01
Epub
2016-00-01
Pages
588-596
Language
English
Region
Austria
NLM ID
101632887
PMCID
PMC5348978
External Links
PubMed source DOI: 10.15698/mic2016.12.546 PMC Full Text View journal details
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