Antibacterial characteristics of YTR 830, a sulfone beta-lactamase inhibitor, compared with those of clavulanic acid and sulbactam.

Antimicrobial agents and chemotherapy ·Vol. 32 ·No. 6 ·1988-06-00 ·Pages 925-7

Moosdeen F, Williams JD, Yamabe S

Abstract

The antibacterial activity, binding to penicillin-binding proteins, and morphological changes effected by YTR 830, a sulfone beta-lactamase inhibitor, were studied in comparison with those of other beta-lactamase inhibitors. YTR 830 had very poor antibacterial activity, bound to PBP 2 of gram-negative organisms, and at the MIC caused rapid lysis of spheroplasts formed.

MeSH Terms

Bacteria/drug effects,ultrastructure Bacterial Proteins Carrier Proteins/metabolism Clavulanic Acids/pharmacology Hexosyltransferases Microbial Sensitivity Tests Muramoylpentapeptide Carboxypeptidase/metabolism Penicillanic Acid/pharmacology Penicillin-Binding Proteins Peptidyl Transferases Sulbactam/pharmacology Tazobactam beta-Lactamase Inhibitors

Chemicals

Bacterial Proteins Carrier Proteins Clavulanic Acids Penicillin-Binding Proteins beta-Lactamase Inhibitors Penicillanic Acid Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase Sulbactam Tazobactam

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Moosdeen F

Department of Medical Microbiology, London Hospital Medical College, England.

Williams J D

Yamabe S

References (13)

13 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.32.6.925

Published

1988-06-00

Pages

925-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC172308

Subset

External Links

PubMed source DOI: 10.1128/AAC.32.6.925 PMC Full Text View journal details

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Antibacterial characteristics of YTR 830, a sulfone beta-lactamase inhibitor, compared with those of clavulanic acid and sulbactam.

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