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PMID: 2846884 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Integration of Friend murine leukemia virus into both alleles of the p53 oncogene in an erythroleukemic cell line.

Journal of virology ·Vol. 62 ·No. 12 ·1988-12-00 ·Pages 4752-5

Hicks GG, Mowat M

Abstract

The Friend virus-transformed erythroleukemic cell line DP16-9B4 has undergone a complex rearrangement of the p53 oncogene and lacks any detectable expression of the p53 protein. We report here characterization of both p53 alleles in this cell line and identify independent integrations of Friend murine leukemia virus sequences into the coding region of both alleles.

MeSH Terms
Alleles Animals Blotting, Southern Cloning, Molecular DNA Restriction Enzymes DNA, Viral/analysis Friend murine leukemia virus/genetics Gene Expression Regulation Leukemia, Erythroblastic, Acute/microbiology Neoplasm Proteins/genetics Nucleic Acid Hybridization Oncogenes Phosphoproteins/genetics Tumor Cells, Cultured Tumor Suppressor Protein p53
Chemicals
DNA, Viral Neoplasm Proteins Phosphoproteins Tumor Suppressor Protein p53 DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hicks G G
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.
Mowat M
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36 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.62.12.4752-4755.1988
Published
1988-12-00
Pages
4752-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253591
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.62.12.4752-4755.1988 PMC Full Text View journal details
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