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PMID: 2891502 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Specific expression of the Hox 1.3 homeo box gene in murine embryonic structures originating from or induced by the mesoderm.

The EMBO journal ·Vol. 6 ·No. 10 ·1987-10-00 ·Pages 2965-75

Dony C, Gruss P

Abstract

The murine Hox 1.3 homeo box-containing gene is expressed largely in mesoderm-derived or mesoderm-induced embryonal structures, as evidenced by in situ hybridization techniques. Expression is spatially limited to the thoracic region, specifically to components of segmental origin such as embryonal ribs and vertebrae and their precursors such as the equivalent sclerotomes, somites and somatic condensations. In addition, expression can be found in parts of embryonal lung, stomach tissue, gut and kidney, tissues whose formation is based on induction of region-specific mesoderm, as well as in some ectoderm-derived tissues. The expression is temporally controlled for the transcripts and can only be detected while the thoracic structures are being formed (days 8-13), but not at day 18 of gestation when the embryo is mature. These data suggest a role of Hox 1.3 gene in the generation of tissues derived from or induced by the embryonal mesoderm.

MeSH Terms
Animals Embryo, Mammalian/cytology Embryonic and Fetal Development Genes, Homeobox Mesoderm/cytology,physiology Mice Nucleic Acid Hybridization Transcription, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dony C
Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, FRG.
Gruss P
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1987-10-00
Pages
2965-75
Language
English
Region
England
NLM ID
8208664
PMCID
PMC553733
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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