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PMID: 2944117 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Expression of the adenovirus E1A oncogene during cell transformation is sufficient to induce susceptibility to lysis by host inflammatory cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 18 ·1986-09-00 ·Pages 6965-9

Cook JL, Walker TA, Lewis AM, Ruley HE, Graham FL, Pilder SH

Abstract

Mammalian cells transformed by nononcogenic human adenoviruses exhibit high susceptibility to destruction by host mononuclear inflammatory cells. We have analyzed the viral gene regulation of the susceptibility of transformed cells to lysis by natural killer cells and activated macrophages. Comparisons of target cell lines transformed by overlapping segments of the adenovirus E1-transforming gene region revealed that isolated expression of a single oncogene, E1A, was sufficient to cause increased cytolytic susceptibility in the absence of detectable transformed cell-surface expression of viral transplantation antigens and irrespective of histocompatibility antigen identity between killer cells and target cells. These results suggest that oncogene functions that are not linked to the expression of previously recognized cell-surface target structures may actively induce neoplastic cell elimination by components of the host immune surveillance system.

MeSH Terms
Adenovirus Early Proteins Adenoviruses, Human/genetics Cell Line Cell Transformation, Neoplastic Cell Transformation, Viral Cytotoxicity, Immunologic Genes, Viral Killer Cells, Natural/immunology Macrophages/immunology Oncogene Proteins, Viral/genetics,physiology Oncogenes Phenotype RNA, Messenger/analysis
Chemicals
Adenovirus Early Proteins Oncogene Proteins, Viral RNA, Messenger
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Cook J L
Walker T A
Lewis A M
Ruley H E
Graham F L
Pilder S H
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36 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.18.6965
Published
1986-09-00
Pages
6965-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC386632
Subset
IM
Grants
NCI NIH HHS · CA 38796 · United States
NCI NIH HHS · CA13106 · United States
NCI NIH HHS · CA38965 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.18.6965 PMC Full Text View journal details
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