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PMID: 2991594 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Sequences outside of the long terminal repeat determine the lymphomogenic potential of Rous-associated virus type 1.

Journal of virology ·Vol. 55 ·No. 3 ·1985-09-00 ·Pages 752-9

Robinson HL, Jensen L, Coffin JM

Abstract

Recombinant avian leukosis viruses have been constructed from the molecularly cloned DNAs of Rous-associated virus type 1 (RAV-1) and Rous-associated virus type 0(RAV-0). Virus encoded by the cloned RAV-1 DNA induced a high incidence of B-cell lymphoma and a moderate incidence of a variety of other neoplasms. Virus encoded by the cloned RAV-0 DNA did not cause disease. Virus recovered from DNA constructions that encoded the gag, pol, and 5' env sequences of RAV-0 and the 3' env and long terminal repeat sequences of RAV-1 did not cause a high incidence of lymphoma. Rather, these constructed viruses induced a low incidence of a variety of neoplasms. Virus recovered from reconstructed pRAV-1 DNA had the same disease potential as did virus recovered from the parental pRAV-1 DNA. These results indicate that the long terminal repeat sequences of RAV-1 do not confer the potential to induce a high incidence of B-cell lymphoma.

MeSH Terms
Animals Avian Leukosis Virus/genetics,isolation & purification B-Lymphocytes Base Sequence Chickens DNA, Recombinant Genes, Viral Lymphoma/genetics,microbiology Viral Proteins
Chemicals
DNA, Recombinant Viral Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Robinson H L
Jensen L
Coffin J M
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.55.3.752-759.1985
Published
1985-09-00
Pages
752-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255059
Subset
IM
Grants
NCI NIH HHS · CA 17659 · United States
NCI NIH HHS · CA 23086 · United States
NCI NIH HHS · CA 27223 · United States
External Links
PubMed source DOI: 10.1128/JVI.55.3.752-759.1985 PMC Full Text View journal details
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