Home LiteratureArticle Details

PMID: 3000766 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Human proto-oncogene c-mos maps to 8q11.

The EMBO journal ·Vol. 4 ·No. 9 ·1985-09-00 ·Pages 2245-8

Caubet JF, Mathieu-Mahul D, Bernheim A, Larsen CJ, Berger R

Abstract

The c-mos proto-oncogene is the cellular counterpart of the viral oncogene v-mos isolated from Moloney murine sarcoma virus. The c-mos gene locus has previously been assigned to human chromosome 8. By both in situ hybridization and molecular hydridization to sorted chromosome DNA (using a c-mos probe) we have localized the c-mos gene to band 8q11. This regional localization is at variance with the one previously reported at 8q22 and may explain why no rearrangement of c-mos has been found in acute leukaemia with the chromosomal translocation t(8;21)(q22;q22).

MeSH Terms

Animals Cell Line Cells, Cultured Chromosome Banding Chromosomes, Human, 6-12 and X Cloning, Molecular Humans Karyotyping Leukemia, Lymphoid Lymphocytes/cytology Metaphase Mice Moloney murine sarcoma virus/genetics Nucleic Acid Hybridization Plasmids Protein Biosynthesis Proto-Oncogene Mas Proto-Oncogenes Sarcoma Viruses, Murine/genetics Translocation, Genetic

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Caubet J F

Mathieu-Mahul D

Bernheim A

Larsen C J

Berger R

References (14)

14 references, click to expand

Chromosome rearrangements in acquired malignant diseases. Oslo Conference (1981): Sixth International Workshop on Human Gene Mapping.
Cytogenet Cell Genet. 1982;32(1-4):205-7 PMID: 7140363
Two human c-onc genes are located on the long arm of chromosome 8.
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7842-6 PMID: 6961456
A simple method for R-banding combined with in situ hybridization.
Hum Genet. 1983;63(3):303 PMID: 6852831
Rearranged c-mos locus in a MOPC 21 murine myeloma cell line and its persistence in hybridomas.
Nature. 1983 Dec 22-1984 Jan 4;306(5945):795-6 PMID: 6656882
Direct hybridization of sorted human chromosomes: localization of the Y chromosome on the flow karyotype.
Proc Natl Acad Sci U S A. 1983 Dec;80(24):7571-5 PMID: 6584872
An improved method for G-banding chromosomes after in situ hybridization.
Cytogenet Cell Genet. 1984;38(4):308-9 PMID: 6439479
Molecular cloning and chromosomal mapping of a human locus related to the transforming gene of Moloney murine sarcoma virus.
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5210-4 PMID: 6291031
Isolation and analysis of the 21q+ chromosome in the acute myelogenous leukemia 8;21 translocation: evidence that c-mos is not translocated.
Proc Natl Acad Sci U S A. 1985 Jan;82(2):464-8 PMID: 2982159
The characterization of high-resolution G-banded chromosomes of man.
Chromosoma. 1978 Aug 14;67(4):293-307 PMID: 357112
Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus.
Science. 1980 Mar 14;207(4436):1222-4 PMID: 6243788
A new method for the preparation of metaphase chromosomes for flow analysis.
J Histochem Cytochem. 1981 Jan;29(1):74-8 PMID: 6162882
Localization of single copy DNA sequences of G-banded human chromosomes by in situ hybridization.
Chromosoma. 1981;83(3):431-9 PMID: 7273954
Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus.
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4078-82 PMID: 6287464
Mouse c-mos oncogene activation is prevented by upstream sequences.
Proc Natl Acad Sci U S A. 1984 Dec;81(24):7817-21 PMID: 6096859

Article Info

Journal

The EMBO journal

Abbr.

EMBO J

ISSN

0261-4189

Published

1985-09-00

Pages

2245-8

Language

English

Region

England

NLM ID

8208664

PMCID

PMC554492

Subset

External Links

PubMed source PMC Full Text View journal details

Analysis Services

Human proto-oncogene c-mos maps to 8q11.

Contact

WeChat Official Account