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PMID: 6961456 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Two human c-onc genes are located on the long arm of chromosome 8.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 24 ·1982-12-00 ·Pages 7842-6

Neel BG, Jhanwar SC, Chaganti RS, Hayward WS

Abstract

We have used in situ chromosome hybridization techniques to map the human cellular counterparts (c-onc genes) of the transforming genes of two RNA tumor viruses on human meiotic pachytene and somatic metaphase chromosomes. We find that the human c-mos gene is located on chromosome 8 at a position corresponding to band 8q22 on the somatic map. The human c-myc gene is found on chromosome 8 at position 8q24. These regions on the long arm of chromosome 8 have been previously reported to be involved in specific translocations found in the M-2 subset of acute nonlymphoblastic leukemias. Burkitt lymphoma, and other forms of non-Hodgkin lymphoma, and a familial abnormality that predisposes to renal cell carcinoma. These results suggest that translocations of the human c-mos or c-myc genes may be causally related to neoplastic transformation.

MeSH Terms
Chromosome Banding Chromosome Mapping Chromosomes, Human, 6-12 and X Genes, Viral Humans Nucleic Acid Hybridization Oncogenes Retroviridae/genetics
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Neel B G
Jhanwar S C
Chaganti R S
Hayward W S
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53 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.24.7842
Published
1982-12-00
Pages
7842-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC347445
Subset
IM
Grants
NCI NIH HHS · CA34502 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.24.7842 PMC Full Text View journal details
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