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PMID: 3012113 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Direct detection of exogenous mouse mammary tumor virus sequences in lymphoid cells of BALB/cfC3H female mice.

Journal of virology ·Vol. 59 ·No. 1 ·1986-07-00 ·Pages 159-62

Liegler TJ, Blair PB

Abstract

The presence of exogenous mouse mammary tumor virus (MMTV) (C3H) DNA sequences in lymphoid tissue (spleen, bone marrow, and thymus) and nonlymphoid tissue (liver and kidney) of BALB/cfC3H female mice was directly assessed by DNA hybridization methods. Lymphoid tissues were found positive for integrated MMTV(C3H) sequences in females as young as 4 weeks. In most samples, the level of splenic MMTV(C3H) infection was low (2 to 5%). Infection remained throughout the life of the animal. The percentage of spleen samples found positive for exogenous viral infection was significantly higher in females bearing mammary tumors, whether virgin or multiparous. Liver and kidney DNAs were negative for exogenous MMTV sequences, suggesting tissue type selectivity in MMTV infection.

MeSH Terms
Age Factors Animals DNA, Neoplasm/analysis DNA, Viral/analysis Female Lymphocytes/analysis,microbiology Lymphoid Tissue/microbiology Mammary Neoplasms, Experimental/analysis Mammary Tumor Virus, Mouse/analysis,growth & development Mice Mice, Inbred Strains Parity
Chemicals
DNA, Neoplasm DNA, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Liegler T J
Blair P B
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35 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.59.1.159-162.1986
Published
1986-07-00
Pages
159-62
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253051
Subset
IM
Grants
NCI NIH HHS · CA-05388 · United States
NIGMS NIH HHS · GM07127 · United States
External Links
PubMed source DOI: 10.1128/JVI.59.1.159-162.1986 PMC Full Text View journal details
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