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PMID: 3018749 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 18 ·1986-09-00 ·Pages 6868-72

Morse HC, Hartley JW, Fredrickson TN, Yetter RA, Majumdar C, Cleveland JL, Rapp UR

Abstract

NFS/N mice were infected within 48 hr of birth with pseudotypes of recombinant murine leukemia viruses containing avian v-myc developed T-cell, pre-B-cell, and B-cell lymphomas and epithelial tumors including pancreatic and mammary adenocarcinomas. Primary hematopoietic and epithelial tumors and continuous in vitro cell lines derived from some of these tumors, established in the absence of added growth factors, exhibited clonal integrations of v-myc and expressed v-myc RNA. These results show that deregulated expression of the myc oncogene in mammalian cells can initiate a wide variety of neoplasms.

MeSH Terms
Adenocarcinoma/etiology Animals Animals, Newborn Cell Line Cell Transformation, Neoplastic Leukemia Virus, Murine/genetics Lymphoma/etiology Mammary Neoplasms, Experimental/etiology Mice Neoplasms, Experimental/etiology,genetics,pathology Oncogenes Recombination, Genetic
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Morse H C
Hartley J W
Fredrickson T N
Yetter R A
Majumdar C
Cleveland J L
Rapp U R
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.18.6868
Published
1986-09-00
Pages
6868-72
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC386611
Subset
IM
Grants
NIAID NIH HHS · N0I-AI-22673 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.18.6868 PMC Full Text View journal details
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