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PMID: 3028777 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter.

The EMBO journal ·Vol. 5 ·No. 12 ·1986-12-01 ·Pages 3243-9

Chevallier-Greco A, Manet E, Chavrier P, Mosnier C, Daillie J, Sergeant A

Abstract

We have identified two Epstein--Barr virus (EBV) transacting factors which are involved in the transcriptional activation of EBV early promoters in latently infected Raji cells. In Raji cells, expression of the factor EB1 encoded by the open reading frame (ORF) BZLF1 is necessary and sufficient to disrupt latency. However, factor EB2 encoded by the ORF BMLF1- BSLF2 does not disrupt latency when expressed alone in Raji cells. Expression of an EBV activatable early promoter depends on the presence of both EB1 and EB2.

MeSH Terms
Cell Line Gene Products, tat Genes Genes, Viral Herpesvirus 4, Human/genetics Humans Promoter Regions, Genetic Transcription Factors/genetics Transcription, Genetic Transfection
Chemicals
Gene Products, tat Transcription Factors
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Chevallier-Greco A
Manet E
Chavrier P
Mosnier C
Daillie J
Sergeant A
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50 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1986-12-01
Pages
3243-9
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1167318
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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