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PMID: 304367 Published · ppublish English Case Reports Journal Article

Evidence for monoclonal proliferation in prolymphocytic leukemia of T-cell orgin. A cytogenetic and Quantitative immunoautoradiographic analysis.

Blut ·Vol. 35 ·No. 6 ·1977-12-00 ·Pages 427-36

Thiel E, Bauchinger M, Rodt H, Huhn D, Theml H, Thierfelder S

Abstract

B- and T-cell markers were studied in a patient with prolymphocytic leukemia, a rare variant of chronic lymphocytic leukemia. Thymus-derived features were identified on the membrane of the neoplastic lymphocytes using the following cellsurface markers: Heterologous T-cell antigen, sheep erythrocyte receptor, surface immunoglobulin, complement receptor, Fc receptor and mouse erythrocyte receptor. Cytogenetic studies of leukemic cells from unstimulated and mitogen-stimulated cultures revealed a consistent karyotype characterized by marker chromosomes and a decreased chromosome number, whereas chromosomal analysis of hair root cells yielded a normal karyotype. A uniform expression of T-cell antigens measured on single leukemic cells by quantitative microphotometric immunoautoradiography correlated with the cytogenetic findings which are compatible with a descent from one progenitor cell.

MeSH Terms
Aged Autoradiography Cell Membrane Complement System Proteins Humans Immunoglobulins Karyotyping Leukemia, Lymphoid/pathology Male T-Lymphocytes/pathology
Chemicals
Immunoglobulins Complement System Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Thiel E
Bauchinger M
Rodt H
Huhn D
Theml H
Thierfelder S
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34 references, click to expand
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Article Info
Journal
Blut
Abbr.
Blut
ISSN
0006-5242
DOI
10.1007/BF00996689
Published
1977-12-00
Pages
427-36
Language
English
Region
Germany
NLM ID
0173401
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00996689
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