Cole-Moore effect in the frog node.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 7 ·1978-07-00 ·Pages 3254-7

Ganot G, Palti Y, Staempfli R

Abstract

Potassium currents were recorded from the voltage-clamped frog node (Rana esculenta) during various test pulses that followed hyperpolarizing prepulses of different amplitudes and durations. Both the delay in potassium current onset and the shape of the current trace as a function of time were found to be a function of prepulse parameters. This finding is different from the current trace superposition described by Cole and Moore for a specific test pulse, sodium equilibrium potential in the squid giant axon. The Cole-Moore effect, which was found here only under a specific set of conditions, thus may be a special case rather than the general property of the membrane. The implication of these findings to the various excitable membrane potassium channel models, which are based on the Cole-Moore effect, is discussed.

MeSH Terms

Animals Anura Electric Conductivity In Vitro Techniques Membrane Potentials Potassium/physiology Rana esculenta/physiology Ranvier's Nodes/physiology

Chemicals

Potassium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ganot G

Palti Y

Staempfli R

References (15)

15 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.75.7.3254

Published

1978-07-00

Pages

3254-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC392753

Subset

External Links

PubMed source DOI: 10.1073/pnas.75.7.3254 PMC Full Text View journal details

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