T-cell nature of leukaemic cells in a case of Sézary's syndrome with 'null-cell' features.

Journal of clinical pathology ·Vol. 32 ·No. 9 ·1979-09-00 ·Pages 912-7

Lauriola L, Musiani P, Carbone A, Bartolini M, Cianciulli P, Piantelli M

Abstract

alpha-naphthyl acetate esterase (ANAE) activity has been investigated in leukaemic cells from peripheral blood in a typical small-cell Sézary syndrome (SS) case in which cerebriform mononuclear cells failed to form E rosettes. The 'dot-like' ANAE positivity found in the majority of these neoplastic cells strongly supports a T-cell origin. In addition, a non-monocytic, non-B-cell nature of Sézary cells is indicated by the lack of Ia-like antigens. Finally, there is evidence of a distinct portion of Sézary cells simultaneously expressing ANAE activity and Fc IgM receptors.

MeSH Terms

Esterases/blood Humans Male Microscopy, Electron Middle Aged Naphthols Receptors, Fc/isolation & purification Rosette Formation Sezary Syndrome/blood,enzymology,immunology T-Lymphocytes/enzymology,immunology,ultrastructure

Chemicals

Naphthols Receptors, Fc Esterases

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Lauriola L

Musiani P

Carbone A

Bartolini M

Cianciulli P

Piantelli M

References (31)

31 references, click to expand

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Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.32.9.912

Published

1979-09-00

Pages

912-7

Language

English

Region

England

NLM ID

0376601

PMCID

PMC1145851

Subset

External Links

PubMed source DOI: 10.1136/jcp.32.9.912 PMC Full Text View journal details

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T-cell nature of leukaemic cells in a case of Sézary's syndrome with 'null-cell' features.

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