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PMID: 318650 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Deoxyribonucleic acid sequence organization of a yeast plasmid.

Journal of bacteriology ·Vol. 129 ·No. 1 ·1977-01-00 ·Pages 472-81

Livingston DM, Klein HL

Abstract

Two-micrometer deoxyribonucleic acid (DNA), a circular plasmid of Saccharomyces cerevisiae, contains two nontandem repeated sequences which are inverted with respect to one another. These repeated sequences together account for 21% of the molecule length. Restriction endonuclease analysis and electron microscopy demonstrated the existence of two forms of 2-mum DNA differing in the orientation of the interstitial segments bounded by the inverted repeated sequences. The two forms of 2-mum DNA could result from an intramolecular reciprocal recombination between inverted repeat elements. A map containing the restriction endonuclease sites and the units of the inverted repeat has been constructed.

MeSH Terms
Base Sequence DNA Restriction Enzymes DNA, Circular/analysis Extrachromosomal Inheritance Nucleic Acid Conformation Plasmids Saccharomyces cerevisiae
Chemicals
DNA, Circular DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Livingston D M
Klein H L
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25 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.129.1.472-481.1977
Published
1977-01-00
Pages
472-81
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC234946
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.129.1.472-481.1977 PMC Full Text View journal details
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