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PMID: 3263646 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 21 ·1988-11-00 ·Pages 8161-5

Iwashima M, Green A, Davis MM, Chien YH

Abstract

A variable region (V delta 5) of the T-cell receptor (TcR) delta chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3' of the constant region (C delta) element. The V delta 5 coding sequence is in a transcriptional orientation opposite the J delta (joining region) and C delta coding elements and rearranges by inversion. The C delta is divided into four exons, three of which encode amino acids of TcR delta polypeptide, and the fourth comprises the entire 3' untranslated region. In this respect, C delta resembles C alpha rather than C beta or C gamma.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Genes, Immunoglobulin Immunoglobulin Constant Regions/genetics Immunoglobulin Variable Region/genetics Mice Molecular Sequence Data Receptors, Antigen, T-Cell/genetics T-Lymphocytes/immunology

Chemicals

Immunoglobulin Constant Regions Immunoglobulin Variable Region Receptors, Antigen, T-Cell

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Iwashima M

Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305.

Green A

Davis M M

Chien Y H

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27 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.85.21.8161

Published

1988-11-00

Pages

8161-5

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC282387

Subset

Databases

GENBANK

M23381, M23382

External Links

PubMed source DOI: 10.1073/pnas.85.21.8161 PMC Full Text View journal details

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Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.

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