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PMID: 3486983 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Group C adenovirus DNA sequences in human lymphoid cells.

Journal of virology ·Vol. 59 ·No. 1 ·1986-07-00 ·Pages 189-92

Horvath J, Palkonyay L, Weber J

Abstract

Human peripheral blood lymphocytes from healthy adults, cord blood lymphocytes, and lymphoblastoid cell lines were screened by hybridization for the presence of group C adenovirus DNA sequences. In 13 of 17 peripheral blood lymphocyte samples from adults, 1 of 10 cord blood samples, and seven of seven lymphoblastoid cell lines tested, results were positive for Group C adenovirus DNA (adenovirus 1 [Ad1], Ad2, Ad5, or Ad6). About 1 to 2% of the lymphocytes carried 50 to 100 viral genome copies per positive cell, as estimated by in situ hybridization. Infectious virus representing all members of group C were recovered, but cultivation in the presence of adenovirus antibody did not cure the cells of free viral genomes. Viral DNA was found in B, T, and N cells but only in 1 of 10 cord blood samples. The results suggest that group C adenovirus infections in childhood result in the persistence of the viral genome in circulating lymphocytes.

MeSH Terms
Adenoviruses, Human/genetics,growth & development Adult Age Factors B-Lymphocytes/microbiology Cell Line DNA, Viral/analysis Fetal Blood/cytology Humans Lymphocytes/microbiology Nucleic Acid Hybridization T-Lymphocytes/microbiology
Chemicals
DNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Horvath J
Palkonyay L
Weber J
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23 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.59.1.189-192.1986
Published
1986-07-00
Pages
189-92
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253058
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.59.1.189-192.1986 PMC Full Text View journal details
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