Persistence of human adenovirus 5 in human cord blood lymphoblastoid cell lines transformed by Epstein-Barr virus.

Infection and immunity ·Vol. 29 ·No. 3 ·1980-09-00 ·Pages 1180-4

Faucon N, Desgranges C

Abstract

Lymphoblastoid cell lines derived from human cord blood leukocytes were persistently infected with human adenovirus 5. These cell lines expressed the Epstein-Barr nuclear antigen, but no other Epstein-Barr virus-related antigen. They continually produced infectious adenovirus 5 particles, but this production could be inhibited by the presence of specific neutralizing antibody to adenovirus 5. This suggests that the persistent infection might be due to the continual reinfection of susceptible cells by complete virus.

MeSH Terms

Adenovirus Infections, Human/microbiology Adenoviruses, Human Animals Antigens Cell Line Cell Nucleus/immunology Cell Transformation, Viral Fetal Blood/microbiology Fluorescent Antibody Technique Herpesvirus 4, Human Humans Leukocytes/microbiology Rabbits

Chemicals

Antigens

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Faucon N

Desgranges C

References (30)

30 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.29.3.1180-1184.1980

Published

1980-09-00

Pages

1180-4

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC551255

Subset

External Links

PubMed source DOI: 10.1128/iai.29.3.1180-1184.1980 PMC Full Text View journal details

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Persistence of human adenovirus 5 in human cord blood lymphoblastoid cell lines transformed by Epstein-Barr virus.

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