Effects of benzodiazepines on psychomotor performance.

British journal of clinical pharmacology ·Vol. 7 Suppl 1 ·1979-00-00 ·Pages 61S-67S

Wittenborn JR

Abstract

1 The literature relating to the effects of benzodiazepines on psychomotor performance is critically reviewed. 2 The multiple and diverse psychomotor tests used are assessed according to their ability to demonstrate differences between drugs. 3 Three general conclusions are: (1) The speed with which simple acts of a repetitive nature are performed may be impaired by benzodiazepines. (2) learning and immediate memory will also be impaired. (3) there is relatively little indication that well established higher mental faculties are adversely involved.

MeSH Terms

Anti-Anxiety Agents/pharmacology Benzodiazepines Flicker Fusion/drug effects Humans Hypnotics and Sedatives Male Motor Skills/drug effects Reaction Time/drug effects Time Perception/drug effects

Chemicals

Anti-Anxiety Agents Hypnotics and Sedatives Benzodiazepines

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Wittenborn J R

References (30)

30 references, click to expand

A review of the effects of diazepam on cognitive and psychomotor performance.
J Nerv Ment Dis. 1975 Dec;161(6):399-414 PMID: 1104773
The effect of diazepam and fentanyl on mental, psychomotor and electroencephalographic functions and their rate of recovery.
Psychopharmacologia. 1975 Oct 14;44(1):61-6 PMID: 1105627
Effects of diazepam and scopolamine on storage, retrieval and organizational processes in memory.
Psychopharmacologia. 1975 Nov 21;44(3):257-62 PMID: 1208760
Critical flicker frequency (CFF) and psychotropic drugs in normal human subjects-a review.
Psychopharmacologia. 1976 May 28;47(2):175-82 PMID: 1273214
Residual effects of hypnotic drugs: evidence for individual differences on vigilance.
Psychopharmacologia. 1976 May 28;47(2):213-6 PMID: 1273220
CHLORDIAZEPOXIDE, DIPIPERON AND AMOBARBITAL. DOSE EFFECT STUDIES ON HUMAN BEINGS.
Psychopharmacologia. 1963 May 21;4:235-46 PMID: 14048544
THE EFFECT OF BENZQUINAMIDE, IN COMPARISON WITH CHLORDIAZEPOXIDE AND PLACEBO, ON PERFORMANCE IN SOME PSYCHOLOGICAL TESTS.
Psychopharmacologia. 1963 Aug 20;4:402-17 PMID: 14048561
DETERMINATION OF RED BLOOD CELL LIFE SPAN.
JAMA. 1964 Apr 27;188:375-8 PMID: 14114025
COMPARATIVE EFFECT IN HUMAN SUBJECTS OF CHLORDIAZEPOXIDE, DIAZEPAM, AND PLACEBO ON MENTAL AND PHYSICAL PERFORMANCE.
Clin Pharmacol Ther. 1965 Mar-Apr;6:139-45 PMID: 14288182
The effect of nitrazepam on manual skill, grip strength, and reaction time with special reference to subjective evaluation of effects on sleep.
Acta Pharmacol Toxicol (Copenh). 1978 Feb;42(2):130-4 PMID: 343500
Psychomotor changes during initial day of benzodiazepine medication.
Br J Clin Pharmacol. 1979;7 Suppl 1:69S-76S PMID: 35208
A clinical study of naproxen-diazepam drug interaction on tests of mood and attention.
Curr Ther Res Clin Exp. 1977 Feb;21(2):149-56 PMID: 403049
Sedative properties of doxepin in comparison with diazepam.
Psychopharmacology (Berl). 1977 Oct 20;54(2):165-9 PMID: 412211
Effects of four commonly-used tranquillizers on low-speed driving performance tests.
Br Med J. 1972 Dec 9;4(5840):580-4 PMID: 4566100
Antianxiety drugs and human performance.
Arch Gen Psychiatry. 1973 Nov;29(5):611-7 PMID: 4589809
Subjective and objective effects of nitrazepam and amylobarbitone sodium in normal human beings.
Psychopharmacologia. 1972;27(4):373-8 PMID: 4648620
The residual effects of flurazepam.
Psychopharmacologia. 1973 Sep 28;32(3):223-35 PMID: 4762232
Efficacy and residual effect evaluation of a new hypnotic, triazolam.
J Clin Pharmacol. 1974 Feb-Mar;14(2):102-11 PMID: 4813079
The effect of medazepam and alcohol on cognitive and motor skills used in car driving.
Psychopharmacologia. 1974 Jun 21;37(4):159-68 PMID: 4844120
Personality, catecholamine metabolites, and psychophysiological response to diazepam.
J Psychiatr Res. 1966 Dec;4(4):221-34 PMID: 4861031
The influence of a new chlordiazepoxide analogue on human mental and motor performance.
J Clin Pharmacol J New Drugs. 1967 Nov-Dec;7(6):330-5 PMID: 4863759
Effects of nitrazepam, amylobarbitone and placebo on some perceptual, motor and cognitive tasks in normal subjects.
Psychopharmacologia. 1969;14(3):167-77 PMID: 4900733
Residual effects of hypnotics.
Psychopharmacologia. 1972;25(2):117-32 PMID: 5048513
The effects of diazepam or diphenhydramine on healthy human subjects.
Psychopharmacologia. 1971;21(3):202-11 PMID: 5095411
Preliminary studies on the central effects of lorazepam, a new benzodiazepine.
J Clin Pharmacol New Drugs. 1971 Nov-Dec;11(6):423-7 PMID: 5211289
The amnesic effect of diazepam (Valium).
Br J Anaesth. 1970 Aug;42(8):690-7 PMID: 5485133
Comparative psychotropic effects of trazodone, imipramine and diazepam in normal subjects.
Curr Ther Res Clin Exp. 1976 Sep;20(3):337-48 PMID: 822990
The effect of minor tranquilizers on psychomotor performance.
Psychopharmacology (Berl). 1976 Jun 23;47(3):281-6 PMID: 823563
A comparison of the effect of imipramine, nomifensine, and placebo on the psychomotor performance of normal males.
Psychopharmacology (Berl). 1976 Dec 21;51(1):85-90 PMID: 827779
The effects of chlordesmethyldiazepam on behavioral performance and subjective judgment in normal subjects.
J Clin Pharmacol. 1976 Oct;16(10 Pt 1):481-88 PMID: 977791

Article Info

Journal

British journal of clinical pharmacology

Abbr.

Br J Clin Pharmacol

ISSN

0306-5251

DOI

10.1111/j.1365-2125.1979.tb04667.x

Published

1979-00-00

Pages

61S-67S

Language

English

Region

England

NLM ID

7503323

PMCID

PMC1429548

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2125.1979.tb04667.x PMC Full Text View journal details

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Effects of benzodiazepines on psychomotor performance.

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