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PMID: 3536482 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28.

The EMBO journal ·Vol. 5 ·No. 10 ·1986-10-00 ·Pages 2697-701

Simon M, Seraphin B, Faye G

Abstract

We have isolated, in yeast, a nuclear gene named KIN28 which presents significant sequence homology with the cell-division-cycle CDC28 gene, with members of the protein-tyrosine kinase family (src, erb, abl, epidermal growth factor, etc.) and those of the family of protein kinases phosphorylating serine and threonine. This strongly suggests that KIN28 is endowed with a protein kinase activity. In contrast with CDC28, KIN28 is interrupted by an intervening sequence. The KIN28 gene failed to complement cdc28 mutations and was shown to be essential for cell proliferation.

MeSH Terms
Amino Acid Sequence Base Sequence Cell Nucleus/physiology Cyclin-Dependent Kinases/genetics Genes Genes, Fungal Protein Kinases/genetics Saccharomyces cerevisiae/enzymology,genetics Saccharomyces cerevisiae Proteins/genetics Sequence Homology, Nucleic Acid
Chemicals
Saccharomyces cerevisiae Proteins Protein Kinases Cyclin-Dependent Kinases Kin28 protein kinase, S cerevisiae
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Simon M
Seraphin B
Faye G
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41 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1986-10-00
Pages
2697-701
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1167171
Subset
IM
Databases
GENBANK
X04423
External Links
PubMed source PMC Full Text View journal details
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