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PMID: 3539011 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess.

Antimicrobial agents and chemotherapy ·Vol. 30 ·No. 4 ·1986-10-00 ·Pages 574-6

Thadepalli H, Gollapudi SV, Chuah SK

Abstract

Difloxacin (A-56619) and A-56620, two novel fluoroquinolones, were tested in comparison with ciprofloxacin, cefoxitin, and combined clindamycin and gentamicin in the treatment of experimentally induced intraabdominal abscess associated with Bacteroides fragilis. Difloxacin was found to be as effective as clindamycin-gentamicin. A-56620, despite achieving subtherapeutic levels in serum, was found to be as effective as cefoxitin. Both difloxacin and A-56620 were effective in vivo against experimentally induced intra-abdominal abscess in rats.

MeSH Terms

Abscess/drug therapy Animals Anti-Bacterial Agents/metabolism,therapeutic use Ascitic Fluid/metabolism Bacteroides Infections/drug therapy Bacteroides fragilis/drug effects Ciprofloxacin/analogs & derivatives,metabolism,therapeutic use Escherichia coli/metabolism Fluoroquinolones Half-Life Male Microbial Sensitivity Tests Rats Rats, Inbred Strains

Chemicals

Anti-Bacterial Agents Fluoroquinolones Ciprofloxacin difloxacin sarafloxacin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Thadepalli H

Gollapudi S V

Chuah S K

References (14)

14 references, click to expand

Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.
Cancer Chemother Rep. 1966 May;50(4):219-44 PMID: 4957125
Simplified, accurate method for antibiotic assay of clinical specimens.
Appl Microbiol. 1966 Mar;14(2):170-7 PMID: 4959982
Experimental intra-abdominal abscesses in rats: development of an experimental model.
Infect Immun. 1974 Dec;10(6):1250-5 PMID: 4611922
Antimicrobial therapy of experimental intraabdominal sepsis.
J Infect Dis. 1975 Sep;132(3):282-6 PMID: 1159331
Therapy for experimental intraabdominal sepsis: comparison of four cephalosporins with clindamycin plus gentamicin.
J Infect Dis. 1977 Mar;135 Suppl:S18-22 PMID: 321707
In vitro activity of ticarcillin against anaerobic bacteria compared with that of carbenicillin and penicillin.
Antimicrob Agents Chemother. 1977 Feb;11(2):258-61 PMID: 848931
In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones.
Antimicrob Agents Chemother. 1986 Feb;29(2):201-8 PMID: 3521473
In vitro antibacterial activity of norfloxacin (MK-0366).
Antimicrob Agents Chemother. 1982 Apr;21(4):604-7 PMID: 6211139
Antimicrobial spectrum of Win 49375.
Antimicrob Agents Chemother. 1984 Jul;26(1):104-7 PMID: 6476813
The activity of enoxacin against clinical bacterial isolates in comparison with that of five other agents, and factors affecting that activity.
J Antimicrob Chemother. 1984 Sep;14 Suppl C:7-17 PMID: 6594324
In vitro susceptibility of anaerobic bacteria to ciprofloxacin (Bay o 9867).
Antimicrob Agents Chemother. 1984 Nov;26(5):785-6 PMID: 6517561
Comparative activity of the quinolones against anaerobic bacteria isolated at community hospitals.
Antimicrob Agents Chemother. 1985 Apr;27(4):657-9 PMID: 3847273
In vitro activities of the quinolone antimicrobial agents A-56619 and A-56620.
Antimicrob Agents Chemother. 1985 Oct;28(4):514-20 PMID: 3935046
Susceptibility of anaerobic bacteria in vitro to 23 antimicrobial agents.
Chemotherapy. 1980;26(5):344-53 PMID: 6446448

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.30.4.574

Published

1986-10-00

Pages

574-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC176483

Subset

External Links

PubMed source DOI: 10.1128/AAC.30.4.574 PMC Full Text View journal details

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Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess.

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