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PMID: 3661560 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

The gene encoding human vimentin is located on the short arm of chromosome 10.

American journal of human genetics ·Vol. 41 ·No. 4 ·1987-10-00 ·Pages 616-26

Ferrari S, Cannizzaro LA, Battini R, Huebner K, Baserga R

Abstract

The gene for vimentin, an intermediate-filament protein, is growth regulated. We used Southern blot analysis and in situ chromosome hybridization to determine the location of the human vimentin gene. Our results show that there is only one copy of the vimentin gene and that it is located on the short arm of chromosome 10 (10pter-10q23) close to the interleukin-2 receptor gene, which is also growth regulated. In situ hybridization studies suggest that the most likely location of the vimentin gene is 10p13. Sequence similarities and homologies of human vimentin to other genes are presented.

MeSH Terms
Animals Chromosome Mapping Chromosomes, Human, Pair 10 Humans Hybrid Cells Mice Sequence Homology, Nucleic Acid Vimentin/genetics
Chemicals
Vimentin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ferrari S
Department of Pathology, Temple University Medical School, Philadelphia, PA 19140.
Cannizzaro L A
Battini R
Huebner K
Baserga R
References (30)
30 references, click to expand
  1. Isolation of high-molecular-weight DNA from mammalian cells.
    Eur J Biochem. 1973 Jul 2;36(1):32-8 PMID: 4200179
  2. Coding sequence and growth regulation of the human vimentin gene.
    Mol Cell Biol. 1986 Nov;6(11):3614-20 PMID: 3467175
  3. A rapid method for detecting and mapping homology between heterologous DNAs. Evaluation of polyomavirus genomes.
    J Biol Chem. 1979 Jun 10;254(11):4876-83 PMID: 220264
  4. Localization of single copy DNA sequences of G-banded human chromosomes by in situ hybridization.
    Chromosoma. 1981;83(3):431-9 PMID: 7273954
  5. Comparison of the proteins of two immunologically distinct intermediate-sized filaments by amino acid sequence analysis: desmin and vimentin.
    Proc Natl Acad Sci U S A. 1981 Jul;78(7):4120-3 PMID: 6945574
  6. Intermediate filaments: a chemically heterogeneous, developmentally regulated class of proteins.
    Annu Rev Biochem. 1982;51:219-50 PMID: 6180679
  7. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.
    Proc Natl Acad Sci U S A. 1982 Dec;79(24):7824-7 PMID: 6961453
  8. Primary and secondary structure of hamster vimentin predicted from the nucleotide sequence.
    Proc Natl Acad Sci U S A. 1983 Jun;80(12):3548-52 PMID: 6304716
  9. Regulation of the cytoskeleton in mesothelial cells: reversible loss of keratin and increase in vimentin during rapid growth in culture.
    Cell. 1983 Aug;34(1):245-53 PMID: 6192933
  10. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
    Anal Biochem. 1983 Jul 1;132(1):6-13 PMID: 6312838
  11. The structure of the vimentin gene.
    Cell. 1983 Nov;35(1):215-23 PMID: 6194898
  12. Molecular cloning of human terminal deoxynucleotidyltransferase.
    Proc Natl Acad Sci U S A. 1984 Jul;81(14):4363-7 PMID: 6087320
  13. Differential control of cytokeratins and vimentin synthesis by cell-cell contact and cell spreading in cultured epithelial cells.
    J Cell Biol. 1984 Oct;99(4 Pt 1):1424-33 PMID: 6207182
  14. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.
    Nature. 1984 Oct 18-24;311(5987):626-31 PMID: 6090948
  15. Remarkable conservation of structure among intermediate filament genes.
    Cell. 1984 Dec;39(3 Pt 2):491-8 PMID: 6210150
  16. An improved method for G-banding chromosomes after in situ hybridization.
    Cytogenet Cell Genet. 1984;38(4):308-9 PMID: 6439479
  17. Structure of a gene for the human epidermal 67-kDa keratin.
    Proc Natl Acad Sci U S A. 1985 Apr;82(7):1896-900 PMID: 2580302
  18. Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.
    Science. 1985 Jun 28;228(4707):1547-9 PMID: 3925551
  19. Chromosome localization of the gene for human terminal deoxynucleotidyltransferase to region 10q23-q25.
    Proc Natl Acad Sci U S A. 1985 Sep;82(17):5836-40 PMID: 3862101
  20. Use of monoclonal antibodies for analyzing the distribution of the intermediate filament protein vimentin in human non-Hodgkin's lymphomas.
    Am J Pathol. 1985 Sep;120(3):351-5 PMID: 2412444
  21. The human desmin and vimentin genes are located on different chromosomes.
    Gene. 1985;38(1-3):189-96 PMID: 4065572
  22. The human gene encoding GM-CSF is at 5q21-q32, the chromosome region deleted in the 5q- anomaly.
    Science. 1985 Dec 13;230(4731):1282-5 PMID: 2999978
  23. Molecular cloning and characterization of the Endo B cytokeratin expressed in preimplantation mouse embryos.
    J Biol Chem. 1986 Jan 15;261(2):538-47 PMID: 2416755
  24. Effect of interleukin-2 on the expression of cell cycle genes in human T lymphocytes.
    Biochem Biophys Res Commun. 1985 Dec 17;133(2):410-6 PMID: 3878709
  25. Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins.
    Nature. 1986 Feb 6-12;319(6053):463-8 PMID: 3453101
  26. The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias.
    Proc Natl Acad Sci U S A. 1986 Mar;83(5):1403-7 PMID: 3006050
  27. Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias.
    Proc Natl Acad Sci U S A. 1986 Apr;83(8):2556-60 PMID: 3458216
  28. Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human.
    Proc Natl Acad Sci U S A. 1986 Jun;83(11):3934-8 PMID: 3520560
  29. Localization of the gene encoding human erythroid-potentiating activity to chromosome region Xp11.1----Xp11.4.
    Am J Hum Genet. 1986 Jun;38(6):819-26 PMID: 3460333
  30. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1987-10-00
Pages
616-26
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1684315
Subset
IM
Grants
NCI NIH HHS · CA10815 · United States
NCI NIH HHS · CA21124 · United States
NCI NIH HHS · CA25898 · United States
External Links
PubMed source PMC Full Text View journal details
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