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PMID: 3458216 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 8 ·1986-04-00 ·Pages 2556-60

Nagarajan L, Louie E, Tsujimoto Y, ar-Rushdi A, Huebner K, Croce CM

Abstract

The human homolog, hpim, of the murine pim-1 gene, which is activated in murine T-cell lymphomas by insertion of retrovirus proviral genomes in the pim-1 region, has been molecularly cloned; the cloned probe has been used to map the hpim locus to human chromosome region 6p21 by somatic cell hybrid analysis and chromosomal in situ hybridization. The hpim gene is expressed as a 3.2-kilobase mRNA in various human cell lines of hematopoietic lineage, most dramatically in the K562 erythroleukemia cell line, which contains a cytogenetically demonstrable rearrangement in the 6p21 region. A characteristic chromosome anomaly, a reciprocal translocation t(6;9)(p21;q33), has been described in myeloid leukemias and could involve the hpim gene.

MeSH Terms
Chromosome Mapping Chromosomes, Human, 6-12 and X Cloning, Molecular Gene Expression Regulation Humans Leukemia/genetics Nucleic Acid Hybridization Proto-Oncogenes RNA, Messenger/genetics Transcription, Genetic Translocation, Genetic
Chemicals
RNA, Messenger
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Nagarajan L
Louie E
Tsujimoto Y
ar-Rushdi A
Huebner K
Croce C M
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41 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.8.2556
Published
1986-04-00
Pages
2556-60
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC323337
Subset
IM
Grants
NCI NIH HHS · CA10815 · United States
NCI NIH HHS · CA21124 · United States
NCI NIH HHS · CA39860 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.8.2556 PMC Full Text View journal details
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