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PMID: 3701921 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Isolation of a retroviruslike sequence from the TL locus of the C57BL/10 murine major histocompatibility complex.

Journal of virology ·Vol. 58 ·No. 2 ·1986-05-00 ·Pages 296-306

Pampeno CL, Meruelo D

Abstract

Two retroviruslike sequences have been isolated from the TL locus of the major histocompatibility complex of C57BL/10 mice. One sequence (TLev2) hybridizes only with probes derived from the pol region of the murine leukemia provirus AKR; the other sequence (TLev1) hybridizes with gag, pol, and env AKR region probes. This 9-kilobase endogenous, TL region-associated virus (TLev1) has been further characterized. The TLev1 genome has been shown to contain murine leukemia virus-related sequences bounded by retroviruslike, VL30 long terminal repeats. Hybridization of TLev1-derived probes to mouse genomic digests reveals multiple copies which show distinct patterns compared with those observed with murine leukemia virus probes. The study of TLev1 may prove significant with respect to the interaction of retroviral sequences within the genome, expression of genes within the TL locus, and polymorphisms within the major histocompatibility complex.

MeSH Terms
AKR murine leukemia virus/genetics Animals Antigens, Neoplasm/genetics Base Sequence Cloning, Molecular Genes, Viral Major Histocompatibility Complex Membrane Glycoproteins Mice Mice, Inbred C57BL/genetics,microbiology Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid Retroviridae/genetics Sequence Homology, Nucleic Acid
Chemicals
Antigens, Neoplasm Membrane Glycoproteins thymus-leukemia antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pampeno C L
Meruelo D
References (60)
60 references, click to expand
  1. Identification of a 30S RNA with properties of a defective type C virus in murine cells.
    J Virol. 1978 Jan;25(1):115-23 PMID: 202730
  2. Primer binding sites corresponding to several tRNA species are present in DNAs of different members of the same retrovirus-like gene family (VL30).
    J Virol. 1985 Apr;54(1):236-9 PMID: 3973981
  3. Virus-like 30S RNA in mouse cells.
    J Virol. 1979 Mar;29(3):1168-76 PMID: 221671
  4. A rapid alkaline extraction procedure for screening recombinant plasmid DNA.
    Nucleic Acids Res. 1979 Nov 24;7(6):1513-23 PMID: 388356
  5. The genome of human papovavirus BKV.
    Cell. 1979 Dec;18(4):963-77 PMID: 229976
  6. Molecular cloning of infectious integrated murine leukemia virus DNA from infected mouse cells.
    Proc Natl Acad Sci U S A. 1980 Jan;77(1):614-8 PMID: 6244569
  7. A simple method of preparing large amounts of phiX174 RF 1 supercoiled DNA.
    Biochim Biophys Acta. 1973 Apr 11;299(4):516-20 PMID: 4575181
  8. Clonal cells lines from a feral mouse embryo which lack host-range restrictions for murine leukemia viruses.
    Virology. 1975 May;65(1):128-34 PMID: 167514
  9. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  10. H-2D control of leukaemia susceptibility: mechanism and implications.
    J Immunogenet. 1980 Feb;7(1):81-90 PMID: 6154752
  11. Heterogeneity of "virus-like" genes encoding retrovirus-associated 30S RNA and their organization within the mouse genome.
    Cell. 1980 Jun;20(2):431-9 PMID: 6248245
  12. Structure of endogenous murine leukemia virus DNA in mouse genomes.
    Proc Natl Acad Sci U S A. 1980 Oct;77(10):5774-8 PMID: 6255464
  13. Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis.
    Nature. 1981 Apr 9;290(5806):475-80 PMID: 6261142
  14. Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes.
    Cell. 1981 Apr;24(1):125-34 PMID: 6786753
  15. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes.
    Nature. 1981 Aug 6;292(5823):506-11 PMID: 6265801
  16. Retroviruses as mutagens: insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus.
    Cell. 1981 Jul;25(1):23-36 PMID: 6268304
  17. Genomes of murine leukemia viruses isolated from wild mice.
    J Virol. 1981 Sep;39(3):777-91 PMID: 6270351
  18. Nucleotide sequence of Moloney murine leukaemia virus.
    Nature. 1981 Oct 15-21;293(5833):543-8 PMID: 6169994
  19. Comparison of the restriction endonuclease maps of unintegrated proviral DNAs from four xenotropic murine leukemia viruses.
    J Virol. 1981 Dec;40(3):963-70 PMID: 6275130
  20. Structure, variation and synthesis of retrovirus long terminal repeat.
    Cell. 1981 Nov;27(1 Pt 2):1-3 PMID: 7326747
  21. Nucleotide sequence of the genome of a murine sarcoma virus.
    Cell. 1981 Nov;27(1 Pt 2):97-108 PMID: 6173134
  22. Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas.
    Nature. 1982 Jan 7;295(5844):25-31 PMID: 6276750
  23. H-2D control of radiation leukemia virus induced neoplasia: evidence for interaction of viral and H-2 genomic information.
    Transplant Proc. 1981 Dec;13(4):1858-62 PMID: 6277058
  24. A convenient and adaptable package of DNA sequence analysis programs for microcomputers.
    Nucleic Acids Res. 1982 Jan 11;10(1):51-9 PMID: 6278412
  25. Clusters of genes encoding mouse transplantation antigens.
    Cell. 1982 Mar;28(3):489-98 PMID: 6280871
  26. Form and function of retroviral proviruses.
    Science. 1982 May 21;216(4548):812-20 PMID: 6177038
  27. Cloning and characterization of an envelope-specific probe from xenotropic murine leukemia proviral DNA.
    J Virol. 1982 Jan;41(1):228-36 PMID: 6283115
  28. Nucleotide sequence of the Akv env gene.
    J Virol. 1982 May;42(2):519-29 PMID: 6283170
  29. Patterns of genomic distribution and sequence heterogeneity of a murine "retrovirus-like" multigene family.
    J Virol. 1982 Jul;43(1):50-8 PMID: 6287016
  30. Internal organization of endogenous proviral DNAs of xenotropic murine leukemia viruses.
    J Virol. 1982 Jul;43(1):8-17 PMID: 6287018
  31. Evidence for an early evolutionary origin and locus polymorphism of mouse VL30 DNA sequences.
    J Virol. 1982 Aug;43(2):511-8 PMID: 7109032
  32. Cloning of endogenous murine leukemia virus-related sequences from chromosomal DNA of BALB/c and AKR/J mice: identification of an env progenitor of AKR-247 mink cell focus-forming proviral DNA.
    J Virol. 1982 Nov;44(2):625-36 PMID: 6292522
  33. Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus.
    Proc Natl Acad Sci U S A. 1982 Nov;79(21):6453-7 PMID: 6292901
  34. Nucleotide sequence of the envelope gene of Friend murine leukemia virus.
    J Virol. 1983 Jan;45(1):1-9 PMID: 6296423
  35. Polyadenylylated RNA complementary to a mouse retrovirus-like multigene family is rapidly and specifically induced by epidermal growth factor stimulation of quiescent cells.
    Proc Natl Acad Sci U S A. 1982 Dec;79(23):7317-21 PMID: 6296829
  36. Nucleotide sequence of the env-specific segment of NFS-Th-1 xenotropic murine leukemia virus.
    J Virol. 1983 Apr;46(1):204-11 PMID: 6298457
  37. Discrete regions of sequence homology between cloned rodent VL30 genetic elements and AKV-related MuLV provirus genomes.
    Nucleic Acids Res. 1983 Jan 25;11(2):305-19 PMID: 6298720
  38. Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.
    Cell. 1983 Apr;32(4):1241-55 PMID: 6301687
  39. Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.
    Proc Natl Acad Sci U S A. 1983 Jun;80(12):3623-7 PMID: 6304726
  40. Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs.
    Cell. 1983 Jun;33(2):379-87 PMID: 6305507
  41. Apparent recombinants between virus-liKE (VL30) and murine leukemia virus-related sequences in mouse DNA.
    J Virol. 1983 Jul;47(1):178-84 PMID: 6306271
  42. Complete nucleotide sequence of the gene for the specific glycoprotein (gp55) of Friend spleen focus-forming virus.
    Proc Natl Acad Sci U S A. 1983 Jul;80(13):3913-7 PMID: 6306650
  43. Thymotropism of murine leukemia virus is conferred by its long terminal repeat.
    Proc Natl Acad Sci U S A. 1983 Jul;80(14):4203-7 PMID: 6308605
  44. Association of endogenous viral loci with genes encoding murine histocompatibility and lymphocyte differentiation antigens.
    Proc Natl Acad Sci U S A. 1983 Aug;80(16):5032-6 PMID: 6308669
  45. Nucleotide sequence of the gp70 gene of murine retrovirus MCF 247.
    J Virol. 1983 Sep;47(3):413-20 PMID: 6312074
  46. Nucleotide sequence analysis of the long terminal repeat of murine virus-like DNA (VL30) and its adjacent sequences: resemblance to retrovirus proviruses.
    J Virol. 1983 Sep;47(3):656-9 PMID: 6620466
  47. Structure and expression of mouse VL30 genes.
    Mol Cell Biol. 1983 Dec;3(12):2221-31 PMID: 6318090
  48. Major pol gene progenitors in the evolution of oncoviruses.
    Science. 1984 Jan 27;223(4634):364-70 PMID: 6197754
  49. Nucleotide sequence of AKV murine leukemia virus.
    J Virol. 1984 Feb;49(2):471-8 PMID: 6319746
  50. Nucleotide sequences of the retroviral long terminal repeats and their adjacent regions.
    Nucleic Acids Res. 1984 Feb 24;12(4):1767-78 PMID: 6322120
  51. 'Solo' large terminal repeats (LTR) of an endogenous retrovirus-like gene family (VL30) in the mouse genome.
    Nucleic Acids Res. 1984 Mar 12;12(5):2273-82 PMID: 6324110
  52. Murine leukemia virus sequences are encoded in the murine major histocompatibility complex.
    Proc Natl Acad Sci U S A. 1984 Mar;81(6):1804-8 PMID: 6324216
  53. Unusual long terminal repeat sequence of a retrovirus transmissible mouse (VL 30) genetic element: identification of functional domains.
    Nucleic Acids Res. 1984 Apr 25;12(8):3445-60 PMID: 6328422
  54. Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells.
    Science. 1984 Jul 27;225(4660):381-5 PMID: 6330891
  55. The biology of Tla.
    Cell. 1984 Aug;38(1):1-2 PMID: 6331890
  56. Retrovirus-induced lethal mutation in collagen I gene of mice is associated with an altered chromatin structure.
    Cell. 1984 Aug;38(1):9-16 PMID: 6088079
  57. Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse.
    Nature. 1984 Aug 23-29;310(5979):650-5 PMID: 6088985
  58. Envelope and long terminal repeat sequences of a cloned infectious NZB xenotropic murine leukemia virus.
    J Virol. 1985 Jan;53(1):100-6 PMID: 2981327
  59. Rous sarcoma virus encodes a transcriptional activator.
    Cell. 1985 Mar;40(3):537-46 PMID: 2982497
  60. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.58.2.296-306.1986
Published
1986-05-00
Pages
296-306
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC252913
Subset
IM
Grants
NCI NIH HHS · CA22247 · United States
NCI NIH HHS · CA31346 · United States
NCI NIH HHS · CA35482 · United States
Databases
GENBANK
M12785, M12786
External Links
PubMed source DOI: 10.1128/JVI.58.2.296-306.1986 PMC Full Text View journal details
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