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PMID: 3863113 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Repeating modular structure of the fibronectin gene: relationship to protein structure and subunit variation.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 19 ·1985-10-00 ·Pages 6571-5

Odermatt E, Tamkun JW, Hynes RO

Abstract

Analysis of the exon-intron structure of the rat fibronectin gene shows that exons correspond precisely with repeating structural units in the protein and that alternative use of some exons produces fibronectin subunits that differ by the presence or absence of certain structural modules. Secondary structure predictions suggest that the repeating structure of the protein is further subdivided into smaller structural units and that these also correspond with exons in the gene.

MeSH Terms
Animals Base Sequence Fibronectins/genetics Humans Organ Specificity Protein Conformation RNA Splicing Rats Recombinant Proteins/genetics Sequence Homology, Nucleic Acid
Chemicals
Fibronectins Recombinant Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Odermatt E
Tamkun J W
Hynes R O
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44 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.19.6571
Published
1985-10-00
Pages
6571-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC391251
Subset
IM
Grants
NCI NIH HHS · P01 CA 26712 · United States
Databases
GENBANK
M11750
External Links
PubMed source DOI: 10.1073/pnas.82.19.6571 PMC Full Text View journal details
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