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PMID: 3922883 Published · ppublish English Comparative Study Journal Article

The influence of Igh-1 genes on the class and subclass distribution of oxazolone-specific antibodies.

Immunogenetics ·Vol. 21 ·No. 5 ·1985-00-00 ·Pages 429-43

László G, Rajnavölgyi E, Andó I, Gergely J

Abstract

Previous studies have demonstrated that the level of the oxazolone-specific antibody response induced by contact sensitization is under the control of H-2 and Igh-1-linked genes. The aim of the present study was to clarify the role of H-2 and Igh-1 genes in the regulation of antibody affinity and isotype composition of oxazolone-specific antibodies. Analysis of the antibody response to oxazolone has revealed different ratios of IgG2a and IgG2b antibodies in mice carrying the Igh-1b allele and in strains carrying alleles a, c, and e. The characteristic ratio of IgG2a and IgG2b isotypes persisted during the whole period of the primary and secondary antibody response of CBA and CBA-Igb Igh-C congenic mice. The Igh-1-linked genes influenced the isotype distribution and not the affinity of oxazolone-specific antibodies induced by contact sensitization.

MeSH Terms
Animals Antibodies/genetics Antibody Formation Antibody Specificity Female Genes, MHC Class II Genetic Linkage Hypersensitivity, Delayed Immunoglobulin G/classification,genetics Male Mice Mice, Inbred Strains Nitrobenzenes/immunology Oxazoles Oxazolone/genetics Species Specificity
Chemicals
Antibodies Immunoglobulin G Nitrobenzenes Oxazoles Oxazolone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
László G
Rajnavölgyi E
Andó I
Gergely J
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44 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00430927
Published
1985-00-00
Pages
429-43
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00430927 View journal details
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